State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, P. R. China.
Org Biomol Chem. 2021 Oct 6;19(38):8301-8306. doi: 10.1039/d1ob01417j.
An efficient method for direct trifluoromethylation and perfluoroalkylation at C3 of imidazopyridines through visible light-promoted C-H bond functionalization was developed. Under the irradiation of a blue LED, a series of C3-perfluoroalkyl-substituted imidazopyridines were synthesized from the corresponding imidazopyridines and perfluoroalkyl iodides in moderate to good yields at room temperature. It should be mentioned that this reaction proceeded in the absence of any transition-metal catalyst, oxidant and photocatalyst.
通过可见光促进的 C-H 键功能化，开发了一种在咪唑并吡啶 C3 位高效进行三氟甲基化和全氟烷基化的方法。在蓝色 LED 的照射下，在室温下，无需任何过渡金属催化剂、氧化剂和光催化剂，相应的咪唑并吡啶和全氟碘代烷反应以中等至良好的收率得到一系列 C3-全氟烷基取代的咪唑并吡啶。
