National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, China.
J Mater Chem B. 2021 May 12;9(18):3912-3924. doi: 10.1039/d1tb00231g.
The surface activation of titanium plays a key role in the biological properties of titanium implants as bone repair materials. Improving the ability to induce apatite precipitation on the surface was a well-accepted titanium bioactivation route. In this study, advanced femtosecond laser microfabrication was applied to modify titanium surfaces, and the effect of femtosecond laser etching on apatite precipitation was investigated and compared with popular titanium modification methods. Meanwhile, the mechanism of apatite formation after femtosecond laser modification was interpreted from the point of materials science. The surface physical-chemical characterization results showed that femtosecond laser etching can improve the surface hydrophilicity and increase the surface energy. Compared with traditional abrasive paper and acid-alkali treatment, this method increased the contents of active sites including titanium oxide and titanium-hydroxyl on titanium surfaces. TiO2 on the surface was transformed to TiO after femtosecond laser treatment. The samples etched with 0.3 W and 0.5 W femtosecond lasers had a better ability to induce apatite deposition than those treated with traditional mechanical treatment and popular acid-alkali modification, which would lead to better bioactivity and osteointegration. Considering the technical advantages of femtosecond lasers in microfabrication, it provides a more efficient and controllable scheme for the bioactivation of titanium. This research would improve the application potential of femtosecond laser treatment, such as micropattern preparation and surface activation, in the field of biomaterials.
钛的表面活化在钛植入物作为骨修复材料的生物特性中起着关键作用。提高在表面上诱导磷灰石沉淀的能力是一种被广泛接受的钛生物活化途径。在这项研究中，先进的飞秒激光微加工被应用于修饰钛表面，并研究了飞秒激光蚀刻对磷灰石沉淀的影响，并与流行的钛改性方法进行了比较。同时，从材料科学的角度解释了飞秒激光改性后磷灰石形成的机制。表面物理化学特性分析结果表明，飞秒激光蚀刻可以提高表面亲水性并增加表面能。与传统的砂纸和酸碱处理相比，这种方法增加了钛表面活性位点的含量，包括氧化钛和钛羟基。飞秒激光处理后，表面上的 TiO2 转化为 TiO。与传统机械处理和流行的酸碱改性相比，功率为 0.3 W 和 0.5 W 的飞秒激光处理的样品具有更好的诱导磷灰石沉积的能力，这将导致更好的生物活性和骨整合。考虑到飞秒激光在微加工方面的技术优势，它为钛的生物活化提供了一种更高效、更可控的方案。这项研究将提高飞秒激光处理在生物材料领域的应用潜力，如微图案制备和表面激活。
