Gastroenterology Unit, Great Ormond Street Hospital, London, United Kingdom.
Pediatric Unit, NESMOS Department, Faculty of Medicine & Psychology, Sapienza University of Rome, S. Andrea University Hospital, Rome, Italy.
Turk J Pediatr. 2021;63(2):307-313. doi: 10.24953/turkjped.2021.02.015.
The main aim of the study was to assess the association between joint hypermobility (JH) and gastrointestinal (GI) disorders in children.
All children aged 4-17 years attending the clinics of the participating Pediatric Gastroenterology Centres for functional GI disorders (FGIDs) and inflammatory bowel disease (IBD) were screened for joint laxity. JH diagnosis was inferred using the Beighton Score. JHS diagnosis was inferred based on the Brighton Criteria. Rome III Diagnostic Criteria were used to diagnose possible FGIDs. Ulcerative colitis and Crohn`s disease diagnoses were made according to the Porto Criteria. Age and sex- matched healthy children were enrolled as controls.
One-hundred-seventy children with GI disorders (70 with FGIDs, 50 with Crohns disease, and 50 with ulcerative colitis) and 100 healthy controls were enrolled in the study. JH was reported in 7/70 (10%) children with FGIDs (p=0.26 compared to controls), 4/50 (8%) children with Crohns disease (p=0.21 compared to controls) and 15/50 (30%) children with ulcerative colitis (p=0.09 compared to controls; p=0.01 compared to FGIDs; p=0.01 compared to Crohn`s).
JH is more prevalent in patients suffering from ulcerative colitis compared to the healthy general population, yet the difference did not reach statistical significance. Likely, a proportion of children with ulcerative colitis and JH may show connective tissue abnormalities. However, whether JH can be considered a possible feature of pediatric GI disorders deserves further investigation.
本研究的主要目的是评估儿童关节过度活动（JH）与胃肠道（GI）疾病之间的关联。
所有 4-17 岁就诊于参与的儿科胃肠病学中心功能性胃肠道疾病（FGIDs）和炎症性肠病（IBD）诊所的儿童均接受关节松弛度筛查。使用 Beighton 评分推断 JH 诊断。根据 Brighton 标准推断 JHS 诊断。使用罗马 III 诊断标准诊断可能的 FGIDs。根据 Porto 标准诊断溃疡性结肠炎和克罗恩病。纳入年龄和性别匹配的健康儿童作为对照。
本研究纳入了 170 名患有 GI 疾病的儿童（70 名 FGIDs 患儿、50 名克罗恩病患儿和 50 名溃疡性结肠炎患儿）和 100 名健康对照儿童。7/70（10%）FGIDs 患儿（p=0.26 与对照组相比）、4/50（8%）克罗恩病患儿（p=0.21 与对照组相比）和 15/50（30%）溃疡性结肠炎患儿（p=0.09 与对照组相比；p=0.01 与 FGIDs 相比；p=0.01 与克罗恩病相比）报告有 JH。
与健康人群相比，患有溃疡性结肠炎的儿童 JH 更为常见，但差异无统计学意义。可能一部分患有溃疡性结肠炎和 JH 的儿童存在结缔组织异常。然而，JH 是否可被视为儿科 GI 疾病的一个可能特征值得进一步研究。
