Saps Miguel, Blom Puck J J, Velasco-Benitez Carlos A, Benninga Marc A
Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Nationwide Children's Hospital, Columbus, OH.
Faculty of Medicine, University of Amsterdam, Amsterdam, The Netherlands.
J Pediatr Gastroenterol Nutr. 2018 Mar;66(3):387-390. doi: 10.1097/MPG.0000000000001724.
The aim of the study was to assess the prevalence of joint hypermobility (JH) among school children with and without functional gastrointestinal disorders (FGIDs). School children completed validated Rome III questionnaires to diagnose FGID. Each child diagnosed with an FGID was matched for age and sex with a healthy control. The prevalence of JH in both groups was compared. A total of 654 school children participated in the study. One hundred forty-eight (22.6%) children were diagnosed with an FGID. Data from 136 FGIDs and 136 healthy controls were analyzed. Joint laxity was assessed to establish the Beighton score (≥4 was considered JH). There was no significant difference in JH between children with and without diagnoses of FGIDs odds ratio (OR) 1.03 (95% confidence interval [CI]: 0.59-1.81, P = 0.89). Multivariate analysis showed that younger age OR 2.31 (95% CI: 1.30-4.10, P = 0.004) and female sex OR 2.27 (95% CI: 1.22-4.24, P = 0.009) were significantly associated with JH. JH is equally prevalent in school children with and without FGIDs.
本研究的目的是评估患有和未患有功能性胃肠疾病（FGID）的学龄儿童关节过度活动（JH）的患病率。学龄儿童完成了经过验证的罗马III问卷以诊断FGID。每例被诊断为FGID的儿童均按年龄和性别与一名健康对照进行匹配。比较了两组中JH的患病率。共有654名学龄儿童参与了本研究。148名（22.6%）儿童被诊断为FGID。分析了136例FGID患儿和136名健康对照的数据。评估关节松弛度以确定Beighton评分（≥4分被视为JH）。患有和未患有FGID的儿童之间JH患病率无显著差异，优势比（OR）为1.03（95%置信区间[CI]：0.59 - 1.81，P = 0.89）。多变量分析显示，年龄较小（OR 2.31，95% CI：1.30 - 4.10，P = 0.004）和女性（OR 2.27，95% CI：1.22 - 4.24，P = 0.009）与JH显著相关。JH在患有和未患有FGID的学龄儿童中同样普遍。
