Xu Chang, Shen Fang-Qi, Feng Gaofeng, Jin Jian
Zhejiang Key Laboratory of Alternative Technologies for Fine Chemicals Process, Shaoxing University, Shaoxing 312000, China.
CAS Key Laboratory of Synthetic Chemistry of Natural Substances, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200032, China.
Org Lett. 2021 May 21;23(10):3913-3918. doi: 10.1021/acs.orglett.1c00984. Epub 2021 Apr 30.
Enabled by electron donor-acceptor complexes, a novel visible-light-induced α-amino C-H bond arylation protocol, without a photoredox catalyst, has been disclosed. The protocol does not require any transition metal, oxidant, or exclusion of oxygen or moisture. A direct irradiation of the mixture of tertiary amines and benzonitriles with visible light in ,-diethylethanamide in the presence of CsCO afforded α-arylated amines in good to excellent yields.
在电子供体-受体配合物的作用下，已公开了一种无需光氧化还原催化剂的新型可见光诱导α-氨基C-H键芳基化反应方案。该方案不需要任何过渡金属、氧化剂，也无需排除氧气或水分。在碳酸铯存在下，在N，N-二乙基乙酰胺中用可见光直接照射叔胺和苄腈的混合物，可得到产率良好至优异的α-芳基化胺。
