与巴鲁赫·坎纳和氯离子相伴的四十四年
Forty Four Years With Baruch Kanner and The Chloride Ion.
机构信息
Department of Pharmacology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT, 06520-8066, USA.
出版信息
Neurochem Res. 2022 Jan;47(1):3-8. doi: 10.1007/s11064-021-03330-0. Epub 2021 Apr 30.
Abstract
Baruch Kanner and this author have had parallel careers investigating neurotransmitter transporters. At multiple times during their careers, they have found themselves collaborating or competing, but always learning from each other. This commentary elaborates on the interactions between the Kanner and Rudnick laboratories, with a focus on transporters in the Neurotransmitter: Sodium Symporter (NSS) family of amino acid and amine transporters. A key focus of these interactions is the mechanism by which chloride ions activate and drive transport.
摘要
巴鲁克·坎纳和本文作者有着相似的职业生涯，都在研究神经递质转运体。在职业生涯的多个阶段，他们要么合作，要么竞争，但总是相互学习。本文述评详述了坎纳和鲁德尼克实验室之间的相互作用，重点关注神经递质：钠协同转运体（NSS）家族的氨基酸和胺转运体。这些相互作用的一个关键焦点是氯离子激活和驱动转运的机制。
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