Powell R W, Blaylock W E, Hoff C J, Chartrand S A
Department of Surgery, University of South Alabama, College of Medicine, Mobile 36617.
J Surg Res. 1988 Jul;45(1):56-9. doi: 10.1016/0022-4804(88)90021-2.
Weanling CD-1 male rats were subjected to 100, 75, and 50% splenectomy. One week following splenectomy, animals received either a sham immunization with 0.1 ml NS or pneumococcal immunization with 0.1 ml of a polyvalent (23) vaccine. Eight weeks following surgery, all animals received an intraperitoneal inoculation with 10(6) Streptococcus pneumoniae Type 3 organisms and were observed for mortality. Significant differences in mortality were seen between sham and immunized animals undergoing 100 or 75% splenectomy, while in the 50% group a difference was noted which did not reach statistical significance (Mantel-Cox log rank test). Patients undergoing greater than 50% splenectomy may be afforded greater protection against overwhelming pneumococcal infections by immunization with pneumococcal vaccine.
将断奶的CD-1雄性大鼠进行100%、75%和50%的脾切除术。脾切除术后一周，动物接受0.1 ml生理盐水的假免疫或0.1 ml多价（23价）疫苗的肺炎球菌免疫。手术后八周，所有动物腹腔接种10⁶ 3型肺炎链球菌，并观察死亡率。在接受100%或75%脾切除术的假免疫动物和免疫动物之间，死亡率存在显著差异，而在50%脾切除组中，差异虽有记录但未达到统计学意义（Mantel-Cox对数秩检验）。接受超过50%脾切除术的患者通过接种肺炎球菌疫苗，可能会获得更强的保护，以抵御暴发性肺炎球菌感染。
