Kwon Minsu, Jeong Yu-Jin, Kwak Jiwon, Jung Kwang-Yoon, Baek Seung-Kuk
Department of Otorhinolaryngology-Head and Neck Surgery, Korea University Anam Hospital, Korea University College of Medicine, Seoul, Korea.
Biostatistics, Korea University Anam Hospital, Korea University College of Medicine, Seoul, Korea.
Oral Dis. 2022 Nov;28(8):2277-2284. doi: 10.1111/odi.13895. Epub 2021 May 10.
In this study, we aimed to determine the relationship between oral health status and thyroid dysfunction.
A population-based cross-sectional analysis using data from the Korean National Health and Nutrition Examination Survey (KNHNES) was performed. We investigated the association between oral health-related parameters and the prevalence of thyroid diseases. In addition, the relationship between oral health status and thyroid function test (TFT) results was analyzed. One-way analysis of variances or chi-square test was used for comparisons between oral health-related parameters and presence of thyroid diseases. Univariable and multivariable logistic regression analyses were conducted to evaluate the associations between participants' characteristics including oral health-related parameters and the abnormal results of TFTs.
A total of 18,034 adults were surveyed. Histories of thyroid diseases were found to be more common in people who brushed their teeth frequently or used oral hygiene products. However, histories of periodontitis and community periodontal index (CPI) did not show significant associations with histories of thyroid diseases. Among 14,860 participants without history of thyroid disorders, people having higher CPI values demonstrated higher probabilities of abnormal TFTs (OR 1.381, 95% CI 1.241-1.537, p < .0001); however, statistical significance was not found after adjusting for the other variables.
Our study demonstrated that good oral health-related behavior was associated with more frequent thyroid disease history. High CPI showed a significant association with TFT abnormalities; however, the significance of this association became lower when other variables such as age and sex were adjusted. Further studies will be needed to determine how the control of oral health-related conditions actually has a causal relationship with thyroid disease/dysfunction through prospective cohort studies.
在本研究中，我们旨在确定口腔健康状况与甲状腺功能障碍之间的关系。
利用韩国国民健康与营养检查调查（KNHNES）的数据进行基于人群的横断面分析。我们调查了口腔健康相关参数与甲状腺疾病患病率之间的关联。此外，还分析了口腔健康状况与甲状腺功能测试（TFT）结果之间的关系。采用单因素方差分析或卡方检验对口腔健康相关参数与甲状腺疾病的存在情况进行比较。进行单变量和多变量逻辑回归分析，以评估包括口腔健康相关参数在内的参与者特征与TFT异常结果之间的关联。
共对18,034名成年人进行了调查。发现甲状腺疾病史在经常刷牙或使用口腔卫生用品的人群中更为常见。然而，牙周炎病史和社区牙周指数（CPI）与甲状腺疾病史之间未显示出显著关联。在14,860名无甲状腺疾病史的参与者中，CPI值较高的人TFT异常的可能性更高（OR 1.381，95% CI 1.241 - 1.537，p <.0001）；然而，在对其他变量进行调整后未发现统计学意义。
我们的研究表明，良好的口腔健康相关行为与更频繁的甲状腺疾病史相关。高CPI与TFT异常存在显著关联；然而，在调整年龄和性别等其他变量后，这种关联的显著性降低。需要进一步的研究通过前瞻性队列研究来确定口腔健康相关状况的控制如何与甲状腺疾病/功能障碍实际存在因果关系。
