Suppr超能文献

采用纳米化自体基质诱导软骨生成术(NAMIC)治疗青少年髌骨剥脱性骨软骨炎:五例报告

Treatment of osteochondritis dissecans of the patella in adolescents with nanofractured autologous matrix-induced chondrogenesis (NAMIC): A report of five cases.

机构信息

Knee Unit, Department of Orthopedic Surgery and Traumatology, Parc Taulí University Hospital, Institut d'Investigació i Innovació Parc Taulí CSPT, Autonomous University of Barcelona, Sabadell, Spain.

Knee Unit, Department of Orthopedic Surgery and Traumatology, Parc Taulí University Hospital, Institut d'Investigació i Innovació Parc Taulí CSPT, Autonomous University of Barcelona, Sabadell, Spain.

出版信息

Knee. 2021 Jun;30:157-162. doi: 10.1016/j.knee.2020.12.026. Epub 2021 Apr 28.

Abstract

PURPOSE

Osteochondritis dissecans (OCD) of the patella is a very rare affliction. The aim of this case series is to evaluate the effectiveness of the Nanofractured Autologous Matrix-Induced Chondrogenesis (NAMIC) technique for the treatment of OCD in young adults.

METHODS

Five consecutive patients with patellar osteochondral lesions treated with NAMIC were prospectively studied. There were 4 males and 1 female with a mean age of 15.2 years, ranging from 12 to 18 years. Clinically, they presented pain when going up and down stairs or squatting, effusion, swelling and functional limitation. The International Cartilage Repair Society (ICRS) grade was III in 4 patients and IV in 1 patient. Patients were functionally evaluated with the Lysholm knee score, the Tegner Activity Score (TAS) and the Knee Injury and Osteoarthritis Outcome Score (KOOS) and radiologically using the Magnetic resonance Observation of Cartilage Repair Tissue (MOCART) score.

RESULTS

All the scores significantly improved two years after surgery with respect to pre-operative values (Lysholm score from 63.8 ± 3.9 before surgery to 91 ± 3.2 at 2 years; Tegner activity score from 3.6 ± 0.5 to 8.2 ± 0.8 and the KOOS score from 45.2 ± 2.6 to 91.2 ± 2.4). Both the X-rays and the Magnetic Resonance Imaging (MRI) showed good joint regularity with an average MOCART of 80 ± 7.1/100.

CONCLUSIONS

Treatment of juvenile patellar osteochondritis dissecans with the NAMIC technique seems to be a reliable technique in the short term to restore the patella joint surface and obtain good functional results.

摘要

目的

髌骨剥脱性骨软骨炎(OCD)是一种非常罕见的疾病。本病例系列研究的目的是评估纳米化自体基质诱导软骨再生(NAMIC)技术治疗青年髌骨骨软骨病变的疗效。

方法

前瞻性研究了 5 例接受 NAMIC 治疗的髌骨骨软骨病变患者。4 例为男性,1 例为女性,平均年龄为 15.2 岁,年龄范围为 12 岁至 18 岁。临床上,他们表现为上下楼梯或下蹲时疼痛、关节积液、肿胀和功能受限。4 例患者的国际软骨修复协会(ICRS)分级为 III 级,1 例为 IV 级。采用 Lysholm 膝关节评分、Tegner 活动评分(TAS)和膝关节损伤和骨关节炎结果评分(KOOS)对患者进行功能评估,采用磁共振软骨修复组织观察评分(MOCART)对患者进行影像学评估。

结果

与术前相比,术后 2 年所有评分均显著改善(Lysholm 评分从术前的 63.8±3.9 分提高到术后的 91±3.2 分;Tegner 活动评分从 3.6±0.5 分提高到 8.2±0.8 分,KOOS 评分从 45.2±2.6 分提高到 91.2±2.4 分)。X 线和磁共振成像(MRI)均显示关节规则性良好,平均 MOCART 评分为 80±7.1/100。

结论

在短期内,NAMIC 技术治疗青少年髌骨剥脱性骨软骨炎似乎是一种可靠的技术,可以恢复髌骨关节面,获得良好的功能结果。

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验