从内生真菌中分离得到的两个新色满-4-酮的分离与鉴定
Isolation and characterization of two new chroman-4-ones from the endophytic fungus obtained from Oliver.
机构信息
Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Department of Neurology, Tianjin Nankai Hospital, Tianjin, China.
出版信息
Nat Prod Res. 2022 Jul;36(13):3297-3302. doi: 10.1080/14786419.2020.1855161. Epub 2020 Dec 1.
Two new chroman-4-ones penicichromanone A () and penicichromanone B (), together with three known compounds conioxepinol C (), emodin () and moniliphenone (), were obtained from the endophytic fungus , which was isolated from the bark of Oliver. The structures of and were elucidated by detailed analysis of HRESIMS, 1D/2D NMR and ECD spectra. All the compounds were evaluated for their anti-inflammatory activities using HEK293 cells, and compounds , , and exhibited significant inhibitory effects on TNF--stimulated NF-κB activation.
从采自 Oliver 树皮的内生真菌 Penicillium sp.中分离得到两个新的色满-4-酮类化合物 penicichromanone A () 和 penicichromanone B (), 以及三个已知化合物 conioxepinol C (), emodin () 和 moniliphenone ()。通过 HRESIMS、1D/2D NMR 和 ECD 光谱的详细分析，确定了 和 的结构。所有化合物均采用 HEK293 细胞进行抗炎活性评价，化合物,, 和 对 TNF--刺激的 NF-κB 激活表现出显著的抑制作用。
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