Xiangya School of Public Health, Central South University, No.238 Shang Ma Yuan Ling Road, Changsha 410008, China.
Institute of Child and Adolescent Health, School of Public Health, Peking University, Beijing, China.
J Clin Lipidol. 2021 May-Jun;15(3):477-487. doi: 10.1016/j.jacl.2021.02.001. Epub 2021 Feb 27.
Current reference values for pediatric dyslipidemia used in China were not developed based on local population studies and did not consider age and sex differences.
In this study, we aimed to determine suitable reference values for total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglyceride (TG), and non-high-density lipoprotein cholesterol (nonHDL-C) for Chinese children and adolescents using a national multicenter school-based study.
A total of 15,830 students aged 6-17 years were recruited from seven provinces of China. Age- and sex-specific percentile values for each lipid indicator were derived based on levels measured in the fasting state, and percentile curves of each indicator were plotted using the LMS method.
Serum lipid levels varied considerably with age in both sexes. Among boys, the cut-off value for high TC, nonHDL-C, LDL-C, and TG, based on the value of the 95th percentiles, ranged from 4.58 to 5.39, 3.34 to 3.99, 2.69 to 3.31, and 1.22 to 1.83 mmol/L, respectively; among girls, the cut-off value for high TC, nonHDL-C, LDL-C, and TC ranged from 5.01 to 5.39, 3.66 to 3.97, 2.97 to 3.32, and 1.41 to 1.93 mmol/L, respectively. The cut-point for low HDL-C ranged from 0.84 to 1.08 mmol/L in boys and from 0.89 to 1.04 mmol/L in girls.
These findings may help to determine age- and sex-specific reference values for serum lipids among Chinese children and adolescents and provide valuable guidance for screening of dyslipidemia.
目前中国使用的儿科血脂异常参考值不是基于当地人群研究制定的，也没有考虑年龄和性别差异。
本研究旨在通过全国多中心的学校基础研究，确定适合中国儿童和青少年的总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）、甘油三酯（TG）和非高密度脂蛋白胆固醇（nonHDL-C）的参考值。
从中国七个省份招募了 15830 名 6-17 岁的学生。根据空腹状态下测量的水平，得出每个脂质指标的年龄和性别特异性百分位数值，并使用 LMS 方法绘制每个指标的百分位曲线。
男女两性的血脂水平随年龄变化较大。在男孩中，根据第 95 百分位数的值，高 TC、非 HDL-C、LDL-C 和 TG 的截止值范围为 4.58-5.39、3.34-3.99、2.69-3.31 和 1.22-1.83mmol/L；在女孩中，高 TC、非 HDL-C、LDL-C 和 TC 的截止值范围为 5.01-5.39、3.66-3.97、2.97-3.32 和 1.41-1.93mmol/L。低 HDL-C 的切点在男孩中为 0.84-1.08mmol/L，在女孩中为 0.89-1.04mmol/L。
这些发现可能有助于确定中国儿童和青少年血清脂质的年龄和性别特异性参考值，并为血脂异常筛查提供有价值的指导。
