University of Leipzig, LIFE Child Leipzig Research Center for Civilization Diseases, Philipp-Rosenthal-Str. 27, 04103, Leipzig, Germany.
University of Leipzig, Hospital for Children and Adolescents, Liebigstr. 20a, 04103, Leipzig, Germany.
BMC Cardiovasc Disord. 2023 Aug 2;23(1):386. doi: 10.1186/s12872-023-03391-9.
To assess the stability of lipid profiles throughout childhood and evaluate their onset and dynamic.
Lipid markers were longitudinally measured in more than 1300 healthy children from the LIFE Child study (Germany) and categorized into normal, at-risk, or adverse. Year-to-year intra-person persistence of the categories during follow-ups was examined and Pearson's correlation coefficient was calculated.
We found strong positive correlations for TC, LDL-C and ApoB (r > 0.75, p < 0.001) from the age of four years. Correlations were lowest during the first two years of life. Most children with normal levels also had normal levels the following year. Children with at-risk levels showed a tendency towards normal levels at the follow-up visit. Adverse levels of TC, LDL-C, ApoB (all ages), and HDL-C (from age 15) persisted in more than half of the affected children. Age-dependent patterns of stability were most pronounced and similar for TC, LDL-C, and ApoB.
Normal levels of serum lipids show high stability and adverse levels stabilized in early childhood for TC, LDL, and ApoB. At-risk and adverse levels of TC, LDL-C or ApoB may warrant further or repeated diagnostic measurements with regards to preventing CVD in the long run.
评估儿童期血脂谱的稳定性，并评估其发病和动态变化。
对来自德国 LIFE Child 研究的 1300 多名健康儿童进行了纵向血脂标志物测量，并将其分为正常、有风险或不良。在随访期间，检查了各分类在个体内的年度持久性，并计算了 Pearson 相关系数。
我们发现，从四岁起，TC、LDL-C 和 ApoB 的相关性非常强（r>0.75，p<0.001）。在生命的头两年，相关性最低。大多数正常水平的儿童次年也保持正常水平。有风险水平的儿童在随访时倾向于正常水平。TC、LDL-C、ApoB（所有年龄）和 HDL-C（15 岁）的不良水平在一半以上的受影响儿童中持续存在。稳定性的年龄依赖性模式在 TC、LDL-C 和 ApoB 中最为明显且相似。
血清脂质的正常水平具有高度稳定性，TC、LDL 和 ApoB 的不良水平在儿童早期趋于稳定。TC、LDL-C 或 ApoB 的有风险和不良水平可能需要进一步或重复的诊断测量，以长期预防 CVD。
