微小病毒 B19 相关移植物失功与异基因造血干细胞移植。
Parvovirus B19-associated graft failure after allogeneic hematopoietic stem cell transplantation.
机构信息
Pediatric Blood and Marrow Transplantation Program, Texas Transplant Institute, Methodist Children's Hospital, San Antonio, Texas, USA.
出版信息
Cancer Rep (Hoboken). 2022 Jan;5(1):e1403. doi: 10.1002/cnr2.1403. Epub 2021 May 1.
Abstract
BACKGROUND
Parvovirus B19 (PVB19) infection has been implicated in allograft failure or dysfunction in solid organ transplantation (SOT) and allogeneic hematopoietic stem cell transplantation (allo-HSCT), but the literature is limited.
CASE
Two pediatric patients were diagnosed with PVB19 infection around the time of allo-HSCT graft failure. Both cases were secondary graft failure and required second allo-HSCT.
CONCLUSION
There are many risk factors and potential confounders in determining the exact etiology of graft failure after allo-HSCT. These two cases highlight the importance of including PVB19 in the diagnostic evaluation for graft failure. PVB19 infection may be an important risk factor for allo-HSCT graft failure.
摘要
背景
细小病毒 B19（PVB19）感染已被牵连入实体器官移植（SOT）和异基因造血干细胞移植（allo-HSCT）中的移植物失败或功能障碍，但文献有限。
病例
两名儿科患者在 allo-HSCT 移植物失败时被诊断为 PVB19 感染。这两个病例都是二次移植物失败，需要进行第二次 allo-HSCT。
结论
在确定 allo-HSCT 后移植物失败的确切病因时，存在许多风险因素和潜在混杂因素。这两个病例强调了在诊断评估移植物失败时将 PVB19 包括在内的重要性。PVB19 感染可能是 allo-HSCT 移植物失败的一个重要危险因素。
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