Department of Medical Physics, Hospital Sant Joan de Reus, IISPV, 43204, Tarragona, Spain.
Department of Radiation Oncology, Hospital Clínic de Barcelona, 08036, Barcelona, Spain.
Med Phys. 2021 Jul;48(7):3413-3424. doi: 10.1002/mp.14914. Epub 2021 May 19.
To investigate (i) the dosimetric leaf gap (DLG) and the effect of the "trailing distance" between leaves from different multileaf collimator (MLC) layers in Halcyon systems and (ii) the ability of the currently available treatment planning systems (TPSs) to approximate this effect.
DICOM plans with transmission beams and sweeping gap tests were created in Python for measuring the DLG for each MLC layer independently and for both layers combined. In clinical Halcyon plans both MLC layers are interchangeably used and leaves from different layers are offset, thus forming a trailing pattern. To characterize the impact of such configuration, new tests called "trailing sweeping gaps" were designed and created where the leaves from one layer follow the leaves from the other layer at a fixed "trailing distance" between the tips. Measurements were carried out on five Halcyons SX2 from different institutions and calculations from both the Eclipse and RayStation TPSs were compared with measurements.
The dose accumulated during a sweeping gap delivery progressively increased with the trailing distance . We call this "the trailing effect." It is most pronounced for between 0 and 5 mm, although some changes were obtained up to 20 mm. The dose variation was independent of the gap size. The measured DLG values also increased with up to 20 mm, again with the steepest variation between 0 and 5 mm. Measured DLG values were negative at = 0 (the leaves from both layers at the same position) but changed sign for ≥ 1 mm, in line with the positive DLG sign usually observed with single-layer rounded-end MLCs. The Eclipse TPS does not explicitly model the leaf tip and, as a consequence, could not predict the dose reduction due to the trailing effect. This resulted in dose discrepancies up to +10% and -8% for the 5 mm sweeping gap and up to ±5% for the 10 mm one depending on the distance . RayStation implements a simple model of the leaf tip that was able to approximate the trailing effect and improved the agreement with measured doses. In particular, with a prototype version of RayStation that assigned a higher transmission at the leaf tip the agreement with measured doses was within ±3% even for the 5 mm gap. The five Halcyon systems behaved very similarly but differences in the DLG around 0.2 mm were found across different treatment units and between MLC layers from the same system. The DLG for the proximal layer was consistently higher than for the distal layer, with differences ranging between 0.10 mm and 0.24 mm.
The trailing distance between the leaves from different layers substantially affected the doses delivered by sweeping gaps and the measured DLG values. Stacked MLCs introduce a new level of complexity in TPSs, which ideally need to implement an explicit model of the leaf tip in order to reproduce the trailing effect. Dynamic tests called "trailing sweeping gaps" were designed that are useful for characterizing and commissioning dual-layer MLC systems.
研究(i)Halcyon 系统中不同多层叶片准直器(MLC)层之间叶片的剂量学叶间隙(DLG)和“滞后距离”的影响,以及(ii)当前可用的治疗计划系统(TPS)模拟该效果的能力。
使用 Python 为每个 MLC 层创建具有传输束和扫隙测试的 DICOM 计划,以独立测量每个 MLC 层的 DLG,并测量两个层的组合 DLG。在临床 Halcyon 计划中,两个 MLC 层可互换使用,并且来自不同层的叶片会偏移,从而形成滞后模式。为了描述这种配置的影响,设计并创建了新的测试,称为“滞后扫隙”,其中一层的叶片以固定的“滞后距离”跟随另一层的叶片。在五个来自不同机构的 Halcyon SX2 上进行了测量,并将 Eclipse 和 RayStation TPS 的计算结果与测量结果进行了比较。
随着滞后距离的增加,扫隙输送过程中累积的剂量逐渐增加。我们称之为“滞后效应”。滞后距离在 0 到 5mm 之间时最为明显,尽管在 20mm 时仍有一些变化。剂量变化与间隙大小无关。测量的 DLG 值也随着滞后距离的增加而增加,在 0 到 5mm 之间的变化最为陡峭。在 =0(两个层的叶片处于同一位置)时,测量的 DLG 值为负,但对于 ≥1mm,测量的 DLG 值会改变符号,这与通常观察到的单层层圆形端 MLC 的正 DLG 符号一致。Eclipse TPS 并未明确模拟叶片尖端,因此无法预测由于滞后效应导致的剂量减少。这导致剂量差异高达+10%和-8%(用于 5mm 扫隙),取决于距离,最高可达±5%(用于 10mm 扫隙)。RayStation 实现了叶片尖端的简单模型,能够近似滞后效应,并提高了与测量剂量的一致性。特别是,使用 RayStation 的原型版本,在叶片尖端分配更高的透射率,即使对于 5mm 的间隙,与测量剂量的一致性也在±3%以内。五个 Halcyon 系统的行为非常相似,但在不同治疗单元之间以及同一系统的 MLC 层之间发现了 DLG 约为 0.2mm 的差异。近侧层的 DLG 始终高于远侧层,差异范围在 0.10mm 和 0.24mm 之间。
来自不同层的叶片之间的滞后距离对扫隙输送的剂量有很大影响,并且测量的 DLG 值也有很大影响。堆叠 MLC 为 TPS 引入了一个新的复杂级别,理想情况下,TPS 需要实现叶片尖端的明确模型,以重现滞后效应。设计了称为“滞后扫隙”的动态测试,这些测试对于表征和调试双层 MLC 系统很有用。