Pediatric Surgery Unit, Surgery Department, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.
Pediatric Surgery Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
J Pediatr Surg. 2022 Mar;57(3):488-491. doi: 10.1016/j.jpedsurg.2021.03.058. Epub 2021 Apr 4.
hypospadias is one of the most widespread male congenital anomalies, occurring in 1:250 to 1:300 live births. Several repair techniques have been developing to improve the outcomes.
a randomized prospective controlled study was adopted to evaluate effectiveness of autologous platelet gel in healing promotion and improving the outcomes of hypospadias repair.
thirty children who aged between 6 months and 12 years were recruited and subdivided into two groups; group A had tubularized incised plate (TIP) repair with autologous platelet gel application and group B had TIP repair without autologous platelet gel.
there was no significant difference in duration of operation between both groups. All patients in groups A and B had slit-like meatus shape in the distal glans. While all those of group A had one urine stream, yet only 11 of group B had one. There were complications that happened exclusively in group B such as spray stream (27%) and fistula (20%). Whereas other complications occurred insignificantly more in group B than in A including meatal stenosis (53 versus 27%), glans dehiscence, (20 versus 7%), bleeding (33 versus 13%), infection (33 versus 27%), edema (27% versus13), respectively. The incidence of skin necrosis was equal in both groups.
autologous platelet gel usage in TIP hypospadias repair can be a reliable technique to promote wound healing, and to limit of postoperative surgical complications.
尿道下裂是最常见的男性先天性畸形之一，每 250 至 300 例活产中就有一例发生。已经开发出几种修复技术来改善治疗效果。
采用随机前瞻性对照研究评估自体血小板凝胶在促进愈合和改善尿道下裂修复效果方面的有效性。
招募了 30 名年龄在 6 个月至 12 岁之间的儿童，并将他们分为两组；A 组采用管状切开板（TIP）修复术，并应用自体血小板凝胶；B 组采用 TIP 修复术，不应用自体血小板凝胶。
两组手术时间无显著差异。A 组和 B 组所有患者的龟头远端均呈裂隙状尿道口形状。虽然 A 组所有患者均有单一尿流，但 B 组仅有 11 例患者有单一尿流。B 组发生了一些仅在 B 组发生的并发症，如喷流（27%）和瘘管（20%）。而其他并发症在 B 组的发生率明显高于 A 组，包括尿道口狭窄（53 比 27%）、龟头裂开（20 比 7%）、出血（33 比 13%）、感染（33 比 27%）、水肿（27%比 13%），分别。两组皮肤坏死的发生率相等。
自体血小板凝胶在 TIP 尿道下裂修复中的应用是一种可靠的技术，可以促进伤口愈合，并限制术后手术并发症的发生。
