Division of Metabolism and Diabetes, Faculty of Medicine, Tohoku Medical and Pharmaceutical University, Japan.
Division of Metabolism and Diabetes, Faculty of Medicine, Tohoku Medical and Pharmaceutical University, Japan.
Diabetes Res Clin Pract. 2021 Jun;176:108840. doi: 10.1016/j.diabres.2021.108840. Epub 2021 Apr 30.
Some studies have reported changes in glycemic control of patients with diabetes mellitus under lockdown. However, no previous study examined the impact of the pandemic on glycemic control in patients with diabetes in countries that did not introduce a lockdown such as Japan. This study aimed to assess changes in glycemic control during the pandemic in patients with type 2 diabetes treated at a Japanese clinic.
We conducted a historical cohort study, using electronic medical records of patients with type 2 diabetes who visited our clinic between January 2019 and August 2020. Differences in HbA1c values before and after the outbreak of COVID-19 were the primary outcome, examined using the linear mixed model.
HbA1c values significantly increased from 7.45% to 7.53% after the state of emergency was introduced (n = 1,009). Furthermore, a deterioration in HbA1c values was observed in particular among women, patients aged ≥ 65 years, those with body mass index of ≥ 25 kg/m, and those that were not using insulin.
Glycemic control deteriorated in patients with type 2 diabetes during the pandemic even in a country without a national lockdown.
一些研究报告了糖尿病患者在封锁期间血糖控制的变化。然而，以前没有研究在日本等没有实施封锁的国家，检查大流行对糖尿病患者血糖控制的影响。本研究旨在评估在日本诊所接受治疗的 2 型糖尿病患者在大流行期间血糖控制的变化。
我们进行了一项历史性队列研究，使用了 2019 年 1 月至 2020 年 8 月期间在我们诊所就诊的 2 型糖尿病患者的电子病历。使用线性混合模型，主要观察指标是 COVID-19 爆发前后 HbA1c 值的差异。
在宣布进入紧急状态后，HbA1c 值从 7.45%显著升高至 7.53%（n=1009）。此外，HbA1c 值恶化尤其见于女性、年龄≥65 岁、体重指数≥25kg/m2 和未使用胰岛素的患者。
即使在没有全国封锁的国家，2 型糖尿病患者的血糖控制在大流行期间也会恶化。
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