CRMB Laboratory, Biochemistry Department, Faculty of Basic Medical Sciences, College of Medicine, University of Ibadan, Ibadan, 200004, Nigeria.
CRMB Laboratory, Biochemistry Department, Faculty of Basic Medical Sciences, College of Medicine, University of Ibadan, Ibadan, 200004, Nigeria.
Environ Toxicol Pharmacol. 2021 Aug;86:103667. doi: 10.1016/j.etap.2021.103667. Epub 2021 Apr 29.
Ingestion of perfluorooctanoic acid (PFOA) elicits toxicities in the hepatorenal system. We investigated the effect of PFOA and N-acetylcysteine (NAC) on the hepatorenal function of rats treated thus: control, PFOA (5 mg/kg), NAC (50 mg/kg), PFOA + NAC (5 and 25 mg/kg), and PFOA + NAC (5 and 50 mg/kg). We observed that NAC significantly (p < 0.05) reduced PFOA-induced increase in hepatic and renal function biomarkers of toxicities relative to PFOA alone and alleviated (p < 0.05) decreases in antioxidant status. Increases in oxidative stress and lipid peroxidation in PFOA-treated rats were reverted to normal by NAC and abated increased pro-inflammatory mediators, and decreased anti-inflammatory cytokine both in the hepatorenal system PFOA treated rats. Histology of the kidney and liver indicated that NAC, abated the severity of PFOA-induced damage significantly. Our findings affirm further that oxido-inflammatory mediators involved in PFOA-mediated toxicity can be effectively blocked by NAC through its antioxidant activity.
摄入全氟辛酸（PFOA）会对肝肾系统造成毒性。我们研究了 PFOA 和 N-乙酰半胱氨酸（NAC）对以下处理的大鼠肝肾功能的影响：对照组、PFOA（5mg/kg）、NAC（50mg/kg）、PFOA+NAC（5 和 25mg/kg）和 PFOA+NAC（5 和 50mg/kg）。我们观察到，与单独使用 PFOA 相比，NAC 显著（p<0.05）降低了 PFOA 引起的肝肾功能毒性生物标志物的增加，并缓解了抗氧化状态的降低。NAC 将 PFOA 处理大鼠的氧化应激和脂质过氧化增加恢复正常，并减轻了 PFOA 处理大鼠肝肾系统中促炎介质的增加和抗炎细胞因子的减少。肾脏和肝脏的组织学表明，NAC 显著减轻了 PFOA 引起的损伤的严重程度。我们的研究结果进一步证实，NAC 通过其抗氧化活性，可以有效阻断与 PFOA 介导的毒性相关的氧化炎症介质。
