Department of Mathematical Sciences, Florida Institute of Technology, Melbourne, FL 32940, United States.
Departments of Mathematics and Biomedical Engineering, University of Utah, Salt Lake City, UT 84102, United States.
J Biomech. 2021 Jun 9;122:110398. doi: 10.1016/j.jbiomech.2021.110398. Epub 2021 Apr 29.
The stability of a platelet thrombus under flow is believed to depend strongly on the local hemodynamics and on the thrombus' porosity, permeability, and elasticity. A two-phase continuum model is used to investigate the biomechanics of thrombus stability in stenotic channels. It treats the thrombus as a porous, viscoelastic material moving differently than the background fluid. The dynamic clot-flow interaction is modeled through a frictional drag term. The model explicitly tracks the formation and breaking of interplatelet molecular bonds, which directly determine the viscoelastic property of the thrombus and govern its ability to resist fluid drag. We characterize the stability/fragility of thrombi for various flow speeds, porosities, bond concentrations, and bond types.
人们认为，血小板血栓在流动状态下的稳定性强烈依赖于局部血液动力学和血栓的多孔性、渗透性和弹性。本文采用两相连续介质模型来研究狭窄通道中血栓稳定性的生物力学。该模型将血栓视为一种多孔、粘弹性材料，其运动方式与背景流体不同。通过摩擦阻力项来模拟动态血栓-血流相互作用。该模型明确跟踪血小板间分子键的形成和断裂，这些键直接决定了血栓的粘弹性，并控制其抵抗流体阻力的能力。我们针对不同的流速、孔隙率、键浓度和键类型来表征血栓的稳定性/脆性。
