Liu Yajing, Chen Lushi, Huang Shuyun, Lv Zeping, Hu Lang, Luo Jiali, Shang Pan, Wang Yukai, Xie Haiqun
Department of Neurology, First People's Hospital of Foshan, No.81, Lingnan North Road, Foshan, 528000, Guangdong, China.
National Research Center for Rehabilitation Technical Aids, Rehabilitation Hospital, Beijing Key Laboratory of Rehabilitation Technical Aids for Old-Age Disability, Key Laboratory of Intelligent Control and Rehabilitation Technology of the Ministry of Civil Affairs, Beijing, China.
Neurol Sci. 2022 Jan;43(1):305-311. doi: 10.1007/s10072-021-05271-6. Epub 2021 May 2.
This study aims to investigate the extent to which sleep duration and efficiency are associated with plasma amyloid-β (Aβ) levels in non-demented older people.
This study is a cross-sectional analysis of 305 non-demented older people. Sleep duration and efficiency were assessed used the Pittsburgh Sleep Quality Index. Levels of plasma Aβ were determined by sandwich enzyme-linked immunosorbent assay technique. Associations between sleep variables and plasma Aβ levels were evaluated with multivariable linear regression analysis.
Compared to those with sleep duration > 7 h, participants with sleep duration < 6 h had a higher plasma Aβ level (β = 0.495, 95% CI 0.0770.913, p = 0.021) and Aβ/Aβ ratio (β = 0.101, 95% CI 0.0580.144, p < 0.001). Compared to those with sleep efficiency ≥ 85%, participants with lower sleep efficiency (6574%, <65%) had a higher level of plasma Aβ (<65%: β = 0.627, 95% CI 0.1471.108, p = 0.011) and Aβ/Aβ ratio (6574%: β = 0.052, 95% CI 0.0070.097, p = 0.026; <65%: β = 0.117, 95% CI 0.067~0.168, p < 0.001).
These findings indicated that short sleep duration and low sleep efficiency were associated with a high level of Aβ. A better comprehending of the link between sleep and plasma Aβ levels may lead to effective sleep-based intervention to reduce the risk of Alzheimer's disease.
本研究旨在调查非痴呆老年人的睡眠时间和睡眠效率与血浆β淀粉样蛋白（Aβ）水平之间的关联程度。
本研究是对305名非痴呆老年人进行的横断面分析。使用匹兹堡睡眠质量指数评估睡眠时间和睡眠效率。采用夹心酶联免疫吸附测定技术测定血浆Aβ水平。通过多变量线性回归分析评估睡眠变量与血浆Aβ水平之间的关联。
与睡眠时间>7小时的参与者相比，睡眠时间<6小时的参与者血浆Aβ水平更高（β = 0.495，95%CI 0.0770.913，p = 0.021），Aβ/Aβ比值更高（β = 0.101，95%CI 0.0580.144，p < 0.001）。与睡眠效率≥85%的参与者相比，睡眠效率较低（6574%，<65%）的参与者血浆Aβ水平更高（<65%：β = 0.627，95%CI 0.1471.108，p = 0.011），Aβ/Aβ比值更高（6574%：β = 0.052，95%CI 0.0070.097，p = 0.026；<65%：β = 0.117，95%CI 0.067~0.168，p < 0.001）。
这些发现表明，睡眠时间短和睡眠效率低与高水平的Aβ有关。更好地理解睡眠与血浆Aβ水平之间的联系可能会带来基于睡眠的有效干预措施，以降低患阿尔茨海默病的风险。
