MRC Centre for Transplantation, Guy's Hospital Campus, King's College London, King's Health Partners, London, UK.
Division of Surgery and Interventional Science, University College London, London, UK.
Psychooncology. 2021 Sep;30(9):1420-1429. doi: 10.1002/pon.5700. Epub 2021 May 1.
Several patient-reported outcome measures (PROMs) are available for the assessment of quality of life (QoL), anxiety and depression for testicular cancer (TCa); however, these PROMs have uncertain validation of their psychometric properties for TCa-only cohorts. This systematic review aims to critically analyse and evaluate the psychometric properties of these QoL, anxiety and depression PROMs.
PubMed, EMBASE and PsycInfo were searched by two independent reviewers from inception to August 2020. Evaluative studies that assessed measurement properties of PROM(s) tools used for measuring QoL, anxiety and depression in TCa patients were included. The COnsensus-based Standards for the selection of health status Measurement Instruments (COSMIN) updated criteria for good measurement properties were used in the evaluation of PROM psychometric quality. This systematic review was registered on the PROSPERO database (CRD42020160232).
Of 4,305 abstracts screened, a final eight full-text articles were included in this review. Five general and two TCa-specific PROMs were identified (depression, n = 1; anxiety and depression, n = 2; QoL, n = 4). All studies were incomplete in the validation of nine measurement properties and the modal methodological quality was 'indeterminate'. The European Organisation for Research and Treatment of Cancer Quality -Testicular Cancer 26 questionnaire and CAYA-T had the highest psychometric validation with three out of nine measurement properties being 'sufficient'.
This systematic review identifies a paucity of PROM-validation studies assessing anxiety, depression and QoL in TCa-only cohorts. We recommend further comprehensive and standardised psychometric validation studies of QoL, anxiety and depression PROMs in TCa-only study populations.
有几种患者报告的结局测量工具（PROMs）可用于评估睾丸癌（TCa）患者的生活质量（QoL）、焦虑和抑郁；然而，这些 PROMs 对仅 TC 队列的心理测量特性的验证尚不确定。本系统评价旨在批判性地分析和评估这些用于测量 TCa 患者 QoL、焦虑和抑郁的 PROM 的心理测量特性。
两位独立审查员从成立到 2020 年 8 月在 PubMed、EMBASE 和 PsycInfo 上进行了搜索。纳入了评估 PROM 工具测量特性的评价性研究，这些工具用于测量 TCa 患者的生活质量、焦虑和抑郁。使用共识基础的健康状况测量仪器选择标准（COSMIN）更新的良好测量特性标准来评估 PROM 的心理测量质量。本系统评价已在 PROSPERO 数据库（CRD42020160232）中注册。
在筛选的 4305 篇摘要中，最终有 8 篇全文文章纳入本综述。确定了 5 种一般和 2 种 TCa 特异性 PROM（抑郁，n=1；焦虑和抑郁，n=2；QoL，n=4）。所有研究在 9 项测量特性的验证中均不完整，方法学质量的模态为“不确定”。欧洲癌症研究与治疗组织质量-睾丸癌 26 问卷和 CAYA-T 在 9 项测量特性中有 3 项达到“足够”，具有最高的心理测量验证。
本系统评价发现，缺乏评估仅 TC 队列中焦虑、抑郁和 QoL 的 PROM 验证研究。我们建议进一步对仅 TC 研究人群中的 QoL、焦虑和抑郁 PROM 进行全面和标准化的心理测量验证研究。
