Hertfordshire and Bedfordshire Urological Cancer Centre, Department of Urology, Lister Hospital, East and North Hertfordshire NHS Trust, Stevenage, UK.
School of Physics, Engineering & Computer Science, University of Hertfordshire, UK.
Urol Oncol. 2021 Aug;39(8):455-470. doi: 10.1016/j.urolonc.2021.03.010. Epub 2021 Apr 29.
Microfluidic systems aim to detect sample matter quickly with high sensitivity and resolution, on a small scale. With its increased use in medicine, the field is showing significant promise in prostate cancer diagnosis and management due, in part, to its ability to offer point-of-care testing. This review highlights some of the research that has been undertaken in respect of prostate cancer and microfluidics. Firstly, this review considers the diagnosis of prostate cancer through use of microfluidic systems and analyses the detection of prostate specific antigen, proteins, and circulating tumor cells to highlight the scope of current advancements. Secondly, this review analyses progressions in the understanding of prostate cancer physiology and considers techniques used to aid treatment of prostate cancer, such as the creation of a micro-environment. Finally, this review highlights potential future roles of microfluidics in assisting prostate cancer, such as in exosomal analysis. In conclusion, this review shows the vast scope and application of microfluidic systems and how these systems will ensure advancements to future prostate cancer management.
微流控系统旨在通过小尺寸实现对样本物质的快速、高灵敏度和高分辨率检测。随着微流控技术在医学领域的广泛应用,由于其能够提供即时检测,该领域在前列腺癌的诊断和管理方面显示出了巨大的应用前景。本文主要介绍了与前列腺癌相关的微流控技术的研究进展。首先,本文考虑了通过微流控系统进行前列腺癌诊断,并分析了前列腺特异性抗原、蛋白质和循环肿瘤细胞的检测,以突出当前进展的范围。其次,本文分析了对前列腺癌生理学理解的进展,并考虑了用于辅助前列腺癌治疗的技术,例如微环境的创建。最后,本文强调了微流控技术在辅助前列腺癌方面的潜在未来作用,例如在外泌体分析中的应用。总之,本文展示了微流控系统的广泛范围和应用,以及这些系统如何确保未来前列腺癌管理的进展。