Matkovskaia T V
Probl Endokrinol (Mosk). 1988 Mar-Apr;34(2):34-8.
A scheme of pathogenesis of thymomegaly based on the laboratory findings of 575 children with thymus enlargement, was drawn up to prove that thymus enlargement was not constitutional abnormality in children but thymus pathology. Routine clinical methods, investigation of the body proportions, indices of immunity and adrenocortical and thyroid function were used. Disorder of thymus function and associated changes in the state of some endocrine glands were proved. The clinical picture of thymus enlargement in children was like this: lymphoproliferative and endocrine-metabolic symptoms, compression of the vital organs by the thymus, immunity disorders.
根据575例胸腺肿大儿童的实验室检查结果，制定了胸腺肿大的发病机制方案，以证明儿童胸腺肿大并非体质异常，而是胸腺病变。采用常规临床方法、身体比例检查、免疫指标以及肾上腺皮质和甲状腺功能指标进行研究。结果证实了胸腺功能紊乱以及一些内分泌腺状态的相关变化。儿童胸腺肿大的临床表现如下：淋巴增殖和内分泌代谢症状、胸腺对重要器官的压迫、免疫紊乱。
