Kuz'menko L G, Zaĭrat'iants O V
Pediatriia. 1991(10):16-21.
Sixteen years of observation over a large group of children with the syndrome of the enlarged thymus with the use of up-to-date methods of examining the CNS, immune, endocrine, neuroendocrine systems and the autopsy data allowed the heterogeneity and polymorphism of the given syndrome to be revealed. Both transitory and stable enlargement of the thymus may be observed. The syndrome of the stable-enlarged thymus is likely to be formed in the intrauterine period and postnatally as well. It may be associated and not associated with thymus-dependent immunodeficiency. The morphological investigation of the thymus may show an enlargement of the cortical area with enhanced T lymphocyte proliferation in it or formation of lymphoid follicles. In clinical practice, the syndrome of the stable-enlarged thymus should be differentiated with thymic tumor. The working classification of the syndrome and concept of the pathogenesis of the stable-enlarged thymus are offered.
对一大组患有胸腺肿大综合征的儿童进行了16年的观察，采用最新的中枢神经系统、免疫、内分泌、神经内分泌系统检查方法以及尸检数据，揭示了该综合征的异质性和多态性。胸腺可出现暂时性和持续性肿大。持续性肿大胸腺综合征可能在宫内期及出生后形成。它可能与胸腺依赖性免疫缺陷有关，也可能无关。胸腺的形态学研究可能显示皮质区增大，其中T淋巴细胞增殖增强或形成淋巴滤泡。在临床实践中，持续性肿大胸腺综合征应与胸腺瘤相鉴别。文中提供了该综合征的工作分类及持续性肿大胸腺发病机制的概念。
