急性常压低氧不会增加血液或血浆黏度。

Acute normobaric hypoxia does not increase blood or plasma viscosity.

机构信息

School of Exercise and Nutritional Sciences, San Diego State University, San Diego, CA, USA.

出版信息

Clin Hemorheol Microcirc. 2021;78(4):461-464. doi: 10.3233/CH-211125.

DOI:10.3233/CH-211125

PMID:33935068

Abstract

BACKGROUND

It has previously been reported that chronic hypoxia increases blood viscosity. The increase is usually attributed to polycythemia-induced increases in hematocrit. However, the effect of acute hypoxia in humans on blood viscosity is unknown.

OBJECTIVE

Therefore, the purpose of this study was to determine the effect of acute hypoxia, independent of changes in hematocrit, on blood and plasma viscosity.

METHODS

Nine healthy volunteers breathed room air for 30 min, followed by 30 min of breathing 15% oxygen. Blood samples were collected at the end of both the normoxic and hypoxic conditions. Blood viscosity, plasma viscosity, and hematocrit were measured in each sample.

RESULTS

The mean±SD hemoglobin oxygen saturation significantly (P < 0.05) decreased from 98±1% during normoxia to 87±2% during hypoxia. Hematocrit was essentially identical for the two conditions (42.1% vs. 42.0%). Blood viscosity was not significantly different for the two conditions with a mean of 2.89±0.17 cP during normoxia and 2.83±0.19 cP during hypoxia. Likewise, plasma viscosity was not significantly different for the two conditions with a mean of 1.19±0.04 cP during normoxia and 1.19±0.05 cP during hypoxia.

CONCLUSION

Such results suggest that acute normobaric hypoxia, independent of changes in hematocrit, does not increase blood or plasma viscosity.

摘要

背景

先前已有报道称，慢性缺氧会增加血液黏度。这种增加通常归因于红细胞增多症导致的血细胞比容升高。然而，目前尚不清楚急性缺氧对人体血液黏度的影响。

目的

因此，本研究旨在确定急性缺氧（不伴有血细胞比容变化）对血液和血浆黏度的影响。

方法

9 名健康志愿者先在空气环境中呼吸 30 分钟，然后再呼吸 15%氧气 30 分钟。在两种条件（常氧和缺氧）结束时采集血样。在每个样本中测量血液黏度、血浆黏度和血细胞比容。

结果

平均±标准差血红蛋白氧饱和度在常氧时为 98±1%，在缺氧时显著（P<0.05）下降至 87±2%。两种条件下的血细胞比容基本相同（分别为 42.1%和 42.0%）。两种条件下的血液黏度没有显著差异，常氧时的平均值为 2.89±0.17 cP，缺氧时为 2.83±0.19 cP。同样，两种条件下的血浆黏度也没有显著差异，常氧时的平均值为 1.19±0.04 cP，缺氧时为 1.19±0.05 cP。