Department of Dental Medicine, Karolinska Institutet, Stockholm, Sweden.
Center for psychiatry research Department of Clinical Neurosciences, Karolinska Institutet, Stockholm, Sweden.
Tumour Biol. 2021;43(1):1-9. doi: 10.3233/TUB-200066.
Oral infections associate statistically with cancer.
We hypothesized that certain periodontal microorganisms might specifically link to malignancies in general and set out to investigate this in our ongoing cohort study.
A sample of 99 clinically examined patients from our cohort of 1676 subjects was used to statistically investigate the associations between harboring periodontal microorganisms Aggregatibacter actinomycetemcomitans (A.a), Porphyromonas gingivalis (P.g), Prevotella intermedia (P.i), Tannerella forsythia (T.f) and Treponema denticola (T.d). We used oral infection indexes and the incidence figures of malignancies as registered in 2008-2016 in the Swedish National Cancer Register.
The pathogen A.a showed strong association with malignancy in 32 out of the 99 patients while P.g and P.i were more prevalent among patients without malignancy. In principal component analyses, A.a appeared in the strongest component while the second strongest component consisted of a combination of T.f and T.d. The third component consisted of a combination of P.g and P.i, respectively. Of basic and oral health variables, gingival index appeared to be the strongest expression of inflammation (Eigen value 4.11 and Explained Variance 68.44 percent).
The results partly confirmed our hypothesis by showing that harboring certain periodontal bacteria might link to malignancy. However, the associations are statistical and no conclusions can be drawn about causality.
口腔感染与癌症具有统计学关联。
我们假设某些牙周微生物可能与一般恶性肿瘤有特定联系，并着手在我们正在进行的队列研究中对此进行调查。
从我们 1676 名受试者的队列中抽取了 99 名经过临床检查的患者样本，用于统计调查携带牙周微生物伴放线放线杆菌（A.a）、牙龈卟啉单胞菌（P.g）、中间普氏菌（P.i）、福赛坦纳菌（T.f）和齿密螺旋体（T.d）与恶性肿瘤之间的关联。我们使用口腔感染指数和 2008-2016 年在瑞典国家癌症登记处登记的恶性肿瘤发病率数据。
病原体 A.a 在 99 名患者中的 32 名中与恶性肿瘤有强烈关联，而 P.g 和 P.i 在无恶性肿瘤的患者中更为普遍。在主成分分析中，A.a 出现在最强的成分中，而第二强的成分由 T.f 和 T.d 的组合组成。第三成分由 P.g 和 P.i 的组合组成。在基本和口腔健康变量中，牙龈指数似乎是炎症最强的表达（特征值 4.11，解释方差 68.44%）。
结果部分证实了我们的假设，表明某些牙周细菌的存在可能与恶性肿瘤有关。然而，这些关联是统计学上的，不能得出关于因果关系的结论。
