Int J Gynecol Pathol. 2022 Mar 1;41(2):142-150. doi: 10.1097/PGP.0000000000000791.
Histologic assessment of response to progestogen therapy is a cornerstone of nonsurgical management of atypical hyperplasia/low-grade endometrioid carcinoma. Pathologists are required to assess whether there is ongoing preneoplastic or neoplastic change in the biopsies (often multiple) taken during therapy. There have been few studies documenting the specific histologic changes induced by therapeutic progestogens and currently there are no guidelines on terminology used in this scenario. Given the need for uniformity in reporting and the lack of guidance in the current literature, we initiated an online survey (including questions, categories of reporting, and scanned slides for assessment) which was sent to all members of British Association of Gynaecological Pathologists (BAGP) and the International Society of Gynecological Pathologists (ISGyP) with the aim to assess the variability among pathologists in reporting these specimens and to come up with a consensus-based terminology for reporting of endometrial biopsies from women on progestogen therapy for endometrial atypical hyperplasia/endometrioid carcinoma. In total, 95 pathologists participated in this survey. This manuscript elaborates on the results of the survey with recommendations aimed at promoting uniform terminology in reporting these biopsies.
孕激素治疗反应的组织学评估是非手术治疗非典型增生/低级别子宫内膜样癌的基石。病理学家需要评估在治疗期间（通常是多次）进行的活检中是否存在进行性肿瘤前或肿瘤性变化。很少有研究记录治疗性孕激素引起的特定组织学变化，目前针对这种情况下使用的术语也没有指南。鉴于报告的一致性要求以及当前文献中缺乏指导，我们发起了一项在线调查（包括问题、报告类别和评估的扫描幻灯片），并将其发送给英国妇科病理学家协会（BAGP）和国际妇科病理学家学会（ISGyP）的所有成员，旨在评估病理学家在报告这些标本方面的变异性，并为孕激素治疗子宫内膜非典型增生/子宫内膜样癌的女性的子宫内膜活检报告提出基于共识的术语。共有 95 名病理学家参与了这项调查。本文详细阐述了调查结果，并提出了旨在促进这些活检报告术语统一的建议。
