突触后致密区的Ca2+/钙调蛋白依赖性蛋白激酶分子对分级信息的长期存储可行性。
Feasibility of long-term storage of graded information by the Ca2+/calmodulin-dependent protein kinase molecules of the postsynaptic density.
作者信息
Lisman J E, Goldring M A
机构信息
Department of Biology, Brandeis University, Waltham, MA 02254.
出版信息
Proc Natl Acad Sci U S A. 1988 Jul;85(14):5320-4. doi: 10.1073/pnas.85.14.5320.
Abstract
The feasibility of long-term information storage by brain type II Ca2+/calmodulin-dependent protein kinase molecules is explored. Recent evidence indicates that this protein has switch-like properties. Equations are derived showing that a single kinase holoenzyme could form a bistable switch having the stability necessary to encode long-term memory, and that a group of kinase molecules, such as that contained within the postsynaptic density, could form a device capable of storing graded information.
摘要
研究了脑II型钙/钙调蛋白依赖性蛋白激酶分子进行长期信息存储的可行性。最近的证据表明，这种蛋白质具有类似开关的特性。推导的公式表明，单个激酶全酶可以形成一个具有编码长期记忆所需稳定性的双稳态开关，并且一组激酶分子，例如包含在突触后致密物中的激酶分子，可以形成一个能够存储分级信息的装置。
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本文引用的文献
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