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Topical Application of MS-275 Decreases the Imiquimod-Induced Hyperproliferative Epidermis and Interleukin-23 Expression in the Upper Dermis of BALB/c Mouse.

作者信息

Friedland Matthew H, Mann Emily A, Frankel Daniela N, Chung Hye Jin, McGee Jean S

机构信息

Department of Dermatology, Boston University School of Medicine, Boston, MA, United States.

出版信息

Ann Dermatol. 2021 Apr;33(2):190-192. doi: 10.5021/ad.2021.33.2.190. Epub 2021 Mar 8.

DOI:10.5021/ad.2021.33.2.190
PMID:33935463
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8082010/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/420b/8082010/f8c22c6f32cd/ad-33-190-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/420b/8082010/f8c22c6f32cd/ad-33-190-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/420b/8082010/f8c22c6f32cd/ad-33-190-g001.jpg

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本文引用的文献

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Investigation into the use of histone deacetylase inhibitor MS-275 as a topical agent for the prevention and treatment of cutaneous squamous cell carcinoma in an SKH-1 hairless mouse model.研究组探究了组蛋白去乙酰化酶抑制剂 MS-275 作为一种局部制剂,在 SKH-1 无毛小鼠模型中预防和治疗皮肤鳞状细胞癌的作用。
PLoS One. 2019 Mar 13;14(3):e0213095. doi: 10.1371/journal.pone.0213095. eCollection 2019.
2
Epigenetic therapy and dermatologic disease: moving beyond CTCL.表观遗传疗法与皮肤病:超越蕈样肉芽肿
J Dermatolog Treat. 2019 Feb;30(1):68-73. doi: 10.1080/09546634.2018.1473550. Epub 2018 May 22.
3
Melanoma epigenetics: novel mechanisms, markers, and medicines.
黑色素瘤表观遗传学:新机制、标志物和药物。
Lab Invest. 2014 Aug;94(8):822-38. doi: 10.1038/labinvest.2014.87. Epub 2014 Jun 30.
4
Epigenetic modifications: basic mechanisms and role in cardiovascular disease.表观遗传修饰:基本机制及其在心血管疾病中的作用
Circulation. 2011 May 17;123(19):2145-56. doi: 10.1161/CIRCULATIONAHA.110.956839.
5
Cancer epigenetics reaches mainstream oncology.癌症表观遗传学进入主流肿瘤学领域。
Nat Med. 2011 Mar;17(3):330-9. doi: 10.1038/nm.2305.
6
HDAC inhibition by LBH589 affects the phenotype and function of human myeloid dendritic cells.LBH589 通过抑制组蛋白去乙酰化酶影响人源髓系树突状细胞的表型和功能。
Leukemia. 2011 Jan;25(1):161-8. doi: 10.1038/leu.2010.244. Epub 2010 Nov 19.
7
Under-expression of VHL and over-expression of HDAC-1, HIF-1alpha, LL-37, and IAP-2 in affected skin biopsies of patients with psoriasis.银屑病患者受累皮肤活检中VHL表达不足以及HDAC - 1、HIF - 1α、LL - 37和IAP - 2表达过度。
Int J Dermatol. 2007 Mar;46(3):239-46. doi: 10.1111/j.1365-4632.2006.02962.x.