Epigenetic modifications: basic mechanisms and role in cardiovascular disease.
作者信息
Handy Diane E, Castro Rita, Loscalzo Joseph
机构信息
Cardiovascular Division, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA.
出版信息
Circulation. 2011 May 17;123(19):2145-56. doi: 10.1161/CIRCULATIONAHA.110.956839.
Abstract
摘要
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Genome-wide erasure of DNA methylation in mouse primordial germ cells is affected by AID deficiency.在小鼠原始生殖细胞中，基因组范围的 DNA 甲基化消除受 AID 缺乏的影响。
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Differential DNA methylation correlates with differential expression of angiogenic factors in human heart failure.差异 DNA 甲基化与人类心力衰竭中血管生成因子的差异表达相关。
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