Detour Ahead: Incretin Hormone Signaling Alters Its Intracellular Path as β-Cell Failure Progresses During Diabetes.
作者信息
Hussain Mehboob A, Laimon-Thomson Erinn, Mustafa Syed M, Deck Alexander, Song Banya
机构信息
Department of Internal Medicine, Division of Metabolism, Endocrinology and Diabetes, University of Michigan, Ann Arbor, MI, United States.
College of Literature, Science and Arts, University of Michigan, Ann Arbor, MI, United States.
出版信息
Front Endocrinol (Lausanne). 2021 Apr 15;12:665345. doi: 10.3389/fendo.2021.665345. eCollection 2021.
Abstract
摘要
相似文献
1
Detour Ahead: Incretin Hormone Signaling Alters Its Intracellular Path as β-Cell Failure Progresses During Diabetes.前方绕道：在糖尿病期间，随着β细胞功能衰竭的进展，肠促胰岛素激素信号改变其细胞内途径。
Front Endocrinol (Lausanne). 2021 Apr 15;12:665345. doi: 10.3389/fendo.2021.665345. eCollection 2021.
2
Incretin action in the pancreas: potential promise, possible perils, and pathological pitfalls.在胰腺中的肠促胰岛素作用：潜在的希望、可能的危险和病理性的陷阱。
Diabetes. 2013 Oct;62(10):3316-23. doi: 10.2337/db13-0822. Epub 2013 Jul 1.
3
Is the diminished incretin effect in type 2 diabetes just an epi-phenomenon of impaired beta-cell function?2型糖尿病中肠促胰素效应减弱仅仅是β细胞功能受损的一种附带现象吗？
Diabetes. 2010 May;59(5):1117-25. doi: 10.2337/db09-1899.
4
Effects of chronic exposure of clonal β-cells to elevated glucose and free fatty acids on incretin receptor gene expression and secretory responses to GIP and GLP-1.克隆β细胞长期暴露于高葡萄糖和游离脂肪酸对肠促胰岛素受体基因表达及对 GIP 和 GLP-1 的分泌反应的影响。
Diabetes Obes Metab. 2014 Apr;16(4):357-65. doi: 10.1111/dom.12227. Epub 2013 Nov 20.
5
Pharmacology, physiology, and mechanisms of incretin hormone action.肠降血糖素激素作用的药理学、生理学和机制。
Cell Metab. 2013 Jun 4;17(6):819-837. doi: 10.1016/j.cmet.2013.04.008. Epub 2013 May 16.
6
GIP: no longer the neglected incretin twin?GIP：不再被忽视的肠促胰岛素兄弟？
Sci Transl Med. 2010 Sep 15;2(49):49ps47. doi: 10.1126/scitranslmed.3001027.
7
Genetic variants affecting incretin sensitivity and incretin secretion.影响肠促胰岛素敏感性和肠促胰岛素分泌的遗传变异。
Diabetologia. 2010 Nov;53(11):2289-97. doi: 10.1007/s00125-010-1876-8. Epub 2010 Aug 17.
8
[Incretin and bone].[肠促胰岛素与骨骼]
Clin Calcium. 2009 Sep;19(9):1312-7.
9
Interplay between bone and incretin hormones: A review.骨与肠促胰岛素激素之间的相互作用：综述
Morphologie. 2017 Mar;101(332):9-18. doi: 10.1016/j.morpho.2016.06.004. Epub 2016 Aug 8.
10
Pathophysiology of type 2 diabetes and the role of incretin hormones and beta-cell dysfunction.2型糖尿病的病理生理学以及肠促胰岛素激素和β细胞功能障碍的作用。
JAAPA. 2007 Dec;Suppl:3-8. doi: 10.1097/01720610-200712000-00001.
引用本文的文献
1
ER stress and unfolded protein response (UPR) signaling modulate GLP-1 receptor signaling in the pancreatic islets.内质网应激和未折叠蛋白反应（UPR）信号通路调节胰岛中的胰高血糖素样肽-1受体信号通路。
Mol Cells. 2024 Jan;47(1):100004. doi: 10.1016/j.mocell.2023.12.002. Epub 2023 Dec 15.
2
A review on phytochemical and pharmacological facets of tropical ethnomedicinal plants as reformed DPP-IV inhibitors to regulate incretin activity.综述热带民族药用植物的植物化学和药理学方面，作为新型 DPP-IV 抑制剂调节肠促胰岛素活性。
Front Endocrinol (Lausanne). 2022 Nov 11;13:1027237. doi: 10.3389/fendo.2022.1027237. eCollection 2022.
3
Research progress of coumarins and their derivatives in the treatment of diabetes.香豆素及其衍生物治疗糖尿病的研究进展。
J Enzyme Inhib Med Chem. 2022 Dec;37(1):616-628. doi: 10.1080/14756366.2021.2024526.
本文引用的文献
1
GIP mediates the incretin effect and glucose tolerance by dual actions on α cells and β cells.GIP 通过对 α 细胞和 β 细胞的双重作用来介导肠促胰岛素效应和葡萄糖耐量。
Sci Adv. 2021 Mar 12;7(11). doi: 10.1126/sciadv.abf1948. Print 2021 Mar.
2
Gs/Gq signaling switch in β cells defines incretin effectiveness in diabetes.β细胞中的Gs/Gq 信号转导开关决定了肠促胰岛素在糖尿病中的作用。
J Clin Invest. 2020 Dec 1;130(12):6639-6655. doi: 10.1172/JCI140046.
3
Glucagon stimulates gluconeogenesis by INSP3R1-mediated hepatic lipolysis.胰高血糖素通过 INSP3R1 介导的肝脂解刺激糖异生。
Nature. 2020 Mar;579(7798):279-283. doi: 10.1038/s41586-020-2074-6. Epub 2020 Mar 4.
4
Beta-cell M muscarinic acetylcholine receptors as potential targets for novel antidiabetic drugs.β细胞 M 毒蕈碱型乙酰胆碱受体——新型抗糖尿病药物的潜在靶点
Int Immunopharmacol. 2020 Apr;81:106267. doi: 10.1016/j.intimp.2020.106267. Epub 2020 Feb 7.
5
Glucagon-like peptide 1 (GLP-1).胰高血糖素样肽 1（GLP-1）。
Mol Metab. 2019 Dec;30:72-130. doi: 10.1016/j.molmet.2019.09.010. Epub 2019 Sep 30.
6
The role of membrane excitability in pancreatic β-cell glucotoxicity.膜兴奋性在胰腺β细胞糖毒性中的作用。
Sci Rep. 2019 May 6;9(1):6952. doi: 10.1038/s41598-019-43452-8.
7
Intra-islet glucagon signaling is critical for maintaining glucose homeostasis.胰岛内胰高血糖素信号对于维持血糖稳态至关重要。
JCI Insight. 2019 Apr 23;5(10):127994. doi: 10.1172/jci.insight.127994.
8
β Cell tone is defined by proglucagon peptides through cAMP signaling.β 细胞的功能状态由胰高血糖素原肽通过 cAMP 信号通路来定义。
JCI Insight. 2019 Mar 7;4(5). doi: 10.1172/jci.insight.126742.
9
Nonconventional glucagon and GLP-1 receptor agonist and antagonist interplay at the GLP-1 receptor revealed in high-throughput FRET assays for cAMP.在用于 cAMP 的高通量 FRET 测定中发现，非传统胰高血糖素和 GLP-1 受体激动剂和拮抗剂在 GLP-1 受体上相互作用。
J Biol Chem. 2019 Mar 8;294(10):3514-3531. doi: 10.1074/jbc.RA118.005682. Epub 2019 Jan 8.
10
Insulin Secretion Depends on Intra-islet Glucagon Signaling.胰岛素分泌依赖于胰岛内的胰高血糖素信号。
Cell Rep. 2018 Oct 30;25(5):1127-1134.e2. doi: 10.1016/j.celrep.2018.10.018.
Zotero 插件