Jia Sinong, Li Lei, Xie Li, Zhang Weituo, Zhu Tengteng, Qian Biyun
Hongqiao International Institute of Medicine, Shanghai Tongren Hospital and Faculty of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Clinical Research Institute, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Front Genet. 2021 Apr 14;12:666396. doi: 10.3389/fgene.2021.666396. eCollection 2021.
Lung cancer is the tumor with the highest morbidity and mortality, and has become a global public health problem. The incidence of lung cancer in men has declined in some countries and regions, while the incidence of lung cancer in women has been slowly increasing. Therefore, the aim is to explore whether estrogen-related genes are associated with the incidence and prognosis of lung cancer.
We obtained all estrogen receptor genes and estrogen signaling pathway genes in The Cancer Genome Atlas (TCGA), and then compared the expression of each gene in tumor tissues and adjacent normal tissues for lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC) separately. Survival analysis was performed of the differentially expressed genes in LUAD and LUSC patients separately. The diagnostic and prognostic values of the candidate genes were validated in the Gene Expression Omnibus (GEO) datasets.
We found 5 estrogen receptor genes and 66 estrogen pathway genes in TCGA. A total of 50 genes were differently expressed between tumor tissues and adjacent normal tissues and 6 of the 50 genes were related to the prognosis of LUAD in TCGA. 56 genes were differently expressed between tumor tissues and adjacent normal tissues and none of the 56 genes was related to the prognosis of LUSC in TCGA. GEO datasets validated that the 6 genes () had different expression between tumor tissues and adjacent normal tissues in LUAD, and 3 genes () were related to the prognosis of LUAD.
The expressions of and are related to the pathogenesis and prognosis of LUAD. and may serve as biomarkers in LUAD screening and prognosis prediction in clinical settings.
肺癌是发病率和死亡率最高的肿瘤，已成为全球性公共卫生问题。在一些国家和地区，男性肺癌发病率有所下降，而女性肺癌发病率则在缓慢上升。因此，目的是探讨雌激素相关基因是否与肺癌的发生及预后相关。
我们获取了癌症基因组图谱（TCGA）中的所有雌激素受体基因和雌激素信号通路基因，然后分别比较了肺腺癌（LUAD）和肺鳞状细胞癌（LUSC）肿瘤组织及相邻正常组织中每个基因的表达情况。分别对LUAD和LUSC患者中差异表达基因进行生存分析。在基因表达综合数据库（GEO）数据集中验证候选基因的诊断和预后价值。
我们在TCGA中发现了5个雌激素受体基因和66个雌激素通路基因。肿瘤组织与相邻正常组织之间共有50个基因表达存在差异，其中50个基因中的6个与TCGA中LUAD的预后相关。肿瘤组织与相邻正常组织之间有56个基因表达存在差异，其中56个基因中没有一个与TCGA中LUSC的预后相关。GEO数据集验证了LUAD肿瘤组织与相邻正常组织之间这6个基因（）表达存在差异，且3个基因（）与LUAD的预后相关。
和 的表达与LUAD的发病机制及预后相关。 和 可能作为临床中LUAD筛查及预后预测的生物标志物。
