Lee M A, Flegel P, Cameron O G, Greden J F
Department of Psychiatry, University of Michigan, Ann Arbor.
Psychiatry Res. 1988 Apr;24(1):61-5. doi: 10.1016/0165-1781(88)90140-0.
Acute caffeine administration increases cortisol and converts the dexamethasone suppression test (DST) to nonsuppression in normal humans; data concerning chronic administration as well as effects in depressed patients are minimal. To determine whether caffeine intake influenced DST results in depression, we retrospectively studied the relationship between regular daily caffeine consumption and pretreatment DST status in major depressives. Daily intake was not correlated with either post-DST cortisol levels or symptom ratings. These data suggest that chronic caffeine use is unlikely to be a major factor in dysregulation of the hypothalamic-pituitary-adrenal axis in depression, perhaps because of the development of tolerance.
急性摄入咖啡因会使正常人的皮质醇增加，并使地塞米松抑制试验（DST）转为不被抑制；关于慢性摄入咖啡因以及其对抑郁症患者影响的数据极少。为了确定咖啡因摄入量是否会影响抑郁症患者的DST结果，我们回顾性研究了重度抑郁症患者每日规律摄入咖啡因与治疗前DST状态之间的关系。每日摄入量与DST后皮质醇水平或症状评分均无相关性。这些数据表明，长期使用咖啡因不太可能是抑郁症下丘脑-垂体-肾上腺轴失调的主要因素，可能是由于耐受性的产生。
