Holsboer F, Gerken A, Steiger A, Fass V
Acta Psychiatr Scand. 1984 May;69(5):383-90. doi: 10.1111/j.1600-0447.1984.tb02509.x.
Three-hour cortisol-profiles and cortisol responses to a 1 mg dose of dexamethasone were recorded in 31 depressed patients and nine controls. The data indicate that the likelihood of detecting non-suppressible cortisol concentrations after dexamethasone is significantly increased in depressed patients with a hypersecretion of cortisol. However, a considerable subsample of normosecretors shows abnormal DST results. Conversely, hypersecretion is often associated with dexamethasone suppression. In this study a 1 mg-DST did not reflect the adrenocortical activity with ultimate accuracy. Therefore any attempts which correlate psychopathological or biological data with pituitary-adrenal activity and use a DST-result as measure are criticizable . Data derived from volunteers illustrate that medical factors such as weight-loss, steroid-containing contraceptives and sleep deprivation can make a pituitary-adrenal activity test ambiguous.
记录了31名抑郁症患者和9名对照者的三小时皮质醇曲线以及对1毫克剂量地塞米松的皮质醇反应。数据表明，在皮质醇分泌过多的抑郁症患者中，检测到地塞米松后皮质醇浓度不可抑制的可能性显著增加。然而，相当一部分正常分泌者的地塞米松抑制试验结果异常。相反，分泌过多往往与地塞米松抑制有关。在本研究中，1毫克地塞米松抑制试验并不能完全准确地反映肾上腺皮质活动。因此，任何将心理病理学或生物学数据与垂体-肾上腺活动相关联并将地塞米松抑制试验结果作为衡量标准的尝试都是值得批评的。来自志愿者的数据表明，体重减轻、含类固醇避孕药和睡眠剥夺等医学因素会使垂体-肾上腺活动测试结果不明确。
