Ameli Fereshteh, Panahi Pooneh, Soleimani Vahid
Department of Pathology, Cancer Institute, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Iran.
Iran J Pathol. 2021 Spring;16(2):232-236. doi: 10.30699/IJP.2020.128407.2402. Epub 2020 Dec 21.
Germ cell teratomas belong to non-seminomatous germ cell tumors and account for 95% of malignant testicular tumors. Regarding the current World Health Organization (WHO) criteria, testicular teratomas are divided into prepubertal and post-pubertal subtypes based on patients' age. The term "burned-out testicular tumor" is a very rare condition referring to a regressed testicular tumor which presents with its metastases without any clinical finding in the testicle. Metastasis can be the presentation of post-pubertal teratoma in 22-37% of cases. In scar associated teratoma (burn-out component), the metastasis rate is 66%. We reported a rare case of post-pubertal teratoma in a 34-year-old male who presented with multiple liver masses initially. Liver biopsy revealed poorly differentiated adenocarcinoma probably of gastrointestinal (GI) tract origin. The upper and lower GI endoscopy were normal. Scrotal ultrasonography showed a hypoechoic cystic intratesticular lesion in the left testis. The patient underwent radical orchiectomy and the histopathologic examination revealed post-pubertal teratoma with burned out component. The patient underwent proper treatment and is still under follow up. As a result, in a young male patient who presented with a retroperitoneal mass or poorly differentiated carcinomas of an unknown primary site, using light microscopy and immunohistochemical profiling alone may be inadequate. Therefore, scrotal screening and physical examination of the scrotum and bilateral testis should be considered to exclude possibility of a metastatic progression from a testicular germ cell neoplasia.
生殖细胞畸胎瘤属于非精原细胞性生殖细胞肿瘤,占恶性睾丸肿瘤的95%。根据世界卫生组织(WHO)目前的标准,睾丸畸胎瘤根据患者年龄分为青春期前和青春期后亚型。“消退型睾丸肿瘤”是一种非常罕见的情况,指的是睾丸肿瘤已消退,但出现了转移,而睾丸本身没有任何临床发现。在22%至37%的病例中,转移可能是青春期后畸胎瘤的表现。在瘢痕相关畸胎瘤(消退成分)中,转移率为66%。我们报告了一例罕见的青春期后畸胎瘤病例,患者为一名34岁男性,最初表现为多个肝脏肿块。肝脏活检显示为低分化腺癌,可能起源于胃肠道(GI)。上消化道和下消化道内镜检查均正常。阴囊超声检查显示左侧睾丸内有一个低回声囊性睾丸内病变。患者接受了根治性睾丸切除术,组织病理学检查显示为青春期后畸胎瘤伴消退成分。患者接受了适当的治疗,目前仍在随访中。因此,对于一名出现腹膜后肿块或原发部位不明的低分化癌的年轻男性患者,仅使用光学显微镜和免疫组化分析可能并不足够。因此,应考虑进行阴囊筛查以及对阴囊和双侧睾丸进行体格检查,以排除睾丸生殖细胞肿瘤转移进展的可能性。