Jafroodifar Abtin, Thibodeau Ryan, Goel Atin, Coelho Marlon, Bryant Stephanie, Nguyen Quoc, Mirchia Kavya, Zaccarini Daniel J, Wojtowycz Andrij R
Department of Radiology, SUNY Upstate Medical University, 750 E Adams St, Syracuse, NY 13210, USA.
Department of Pathology, SUNY Upstate Medical University, 750 E Adams St, Syracuse, NY 13210, USA.
Radiol Case Rep. 2021 Apr 15;16(6):1477-1484. doi: 10.1016/j.radcr.2021.03.018. eCollection 2021 Jun.
Chronic lymphocytic leukemia (CLL) is the second most common hematologic malignancy, and it is characterized by lymphocytic leukocytosis and secondary hematologic deficiencies. While it most commonly presents as a systemic disease, extramedullary involvement may rarely occur. The literature surrounding CLL metastatic disease to the gallbladder is particularly sparse. Interestingly, we describe a case of a 67-year-old female who presented with painless jaundice and was found to have a rapidly growing gallbladder wall mass which was determined to be CLL metastatic disease after extensive surgical resection. It is important for radiologists to recognize the possibility of CLL metastatic disease to the gallbladder when evaluating potential cases of cholecystitis due to the overlapping spectrum of imaging findings. Cognizant radiologists can potentially save patients from surgical intervention as CLL is classically treated with chemotherapy.
慢性淋巴细胞白血病（CLL）是第二常见的血液系统恶性肿瘤，其特征为淋巴细胞增多症和继发性血液学缺陷。虽然它最常表现为全身性疾病，但髓外受累可能很少见。关于CLL转移至胆囊的文献特别稀少。有趣的是，我们描述了一例67岁女性病例，该患者出现无痛性黄疸，经检查发现胆囊壁有一个快速生长的肿块，在进行广泛手术切除后确定为CLL转移性疾病。对于放射科医生来说，在评估胆囊炎潜在病例时认识到CLL转移至胆囊的可能性很重要，因为影像学表现有重叠。有经验的放射科医生有可能使患者避免手术干预，因为CLL通常采用化疗进行治疗。
