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一例产后诊断的胰岛素瘤，其低血糖症状在孕期被掩盖。

A case of insulinoma diagnosed postpartum with hypoglycemic symptoms that were masked during pregnancy.

作者信息

Abe Tomoe, Takeda Yasutaka, Takiyama Takao, Sasaki Ayaka, Bessho Ryoichi, Sato Mao, Kitsunai Hiroya, Sakagami Hidemitsu, Abiko Atsuko, Imai Koji, Yuzawa Sayaka, Tanino Mishie, Takiyama Yumi

机构信息

Division of Metabolism and Biosystemic Science Department of Medicine Asahikawa Medical University Asahikawa Japan.

Division of Hepato-Biliary-Pancreatic and Transplant Surgery Department of Surgery Asahikawa Medical University Asahikawa Japan.

出版信息

Clin Case Rep. 2021 Feb 16;9(4):1991-1998. doi: 10.1002/ccr3.3924. eCollection 2021 Apr.

DOI:10.1002/ccr3.3924
PMID:33936628
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8077346/
Abstract

The diagnosis of insulinoma in perinatal women can be difficult, as hypoglycemic symptoms may be masked by pregnancy-associated insulin resistance. In addition, when multiple insulinomas are observed, it is necessary to consider the possibility not only of MEN1, but also of insulinomatosis.

摘要

围产期女性胰岛素瘤的诊断可能很困难，因为低血糖症状可能被妊娠相关的胰岛素抵抗所掩盖。此外，当观察到多个胰岛素瘤时，不仅有必要考虑多发性内分泌腺瘤病1型（MEN1）的可能性，还需考虑胰岛细胞瘤病的可能性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f172/8077346/9281b218bdff/CCR3-9-1991-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f172/8077346/a4e874451dad/CCR3-9-1991-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f172/8077346/e7a150ed9da0/CCR3-9-1991-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f172/8077346/9281b218bdff/CCR3-9-1991-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f172/8077346/a4e874451dad/CCR3-9-1991-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f172/8077346/e7a150ed9da0/CCR3-9-1991-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f172/8077346/9281b218bdff/CCR3-9-1991-g002.jpg

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本文引用的文献

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Insulinoma Identified in Puerperium: Association with Pregnancy and Literature Review.产褥期发现的胰岛素瘤：与妊娠的关联及文献综述
Eur J Case Rep Intern Med. 2020 Mar 16;7(4):001556. doi: 10.12890/2020_001556. eCollection 2020.
2
Pancreatic Neuroendocrine Tumour in Pregnancy - Diagnosis and Treatment Management.妊娠期胰腺神经内分泌肿瘤——诊断与治疗管理
Chirurgia (Bucur). 2019 Sept-Oct;114(5):550-563. doi: 10.21614/chirurgia.114.5.550.
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25-Hydroxyvitamin D profiles and maternal bone mass during pregnancy and lactation in Japanese women.
日本女性在妊娠和哺乳期的 25-羟维生素 D 谱和骨量。
J Bone Miner Metab. 2020 Jan;38(1):99-108. doi: 10.1007/s00774-019-01032-w. Epub 2019 Aug 20.
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Primary Hyperparathyroidism.原发性甲状旁腺功能亢进症。
J Clin Endocrinol Metab. 2018 Nov 1;103(11):3993-4004. doi: 10.1210/jc.2018-01225.
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Physiology of the Calcium-Parathyroid Hormone-Vitamin D Axis.钙-甲状旁腺激素-维生素 D 轴的生理学。
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missense mutation causes familial insulinomatosis and diabetes mellitus.错义突变导致家族性胰岛细胞瘤和糖尿病。
Proc Natl Acad Sci U S A. 2018 Jan 30;115(5):1027-1032. doi: 10.1073/pnas.1712262115. Epub 2018 Jan 16.
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A severe but reversible reduction in insulin sensitivity is observed in patients with insulinoma.在胰岛素瘤患者中观察到胰岛素敏感性严重但可逆转的降低。
Ann Endocrinol (Paris). 2018 Feb;79(1):30-36. doi: 10.1016/j.ando.2017.08.001. Epub 2017 Dec 11.
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Hypoglycemia identified by a continuous glucose monitoring system in a second-trimester pregnant woman with insulinoma: a case report.胰岛素瘤致孕中期孕妇连续血糖监测系统识别低血糖：一例报告
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Insulinoma as rare cause of severe post-partum hypoglycemia.胰岛素瘤是产后严重低血糖的罕见病因。
J Obstet Gynaecol Res. 2015 Nov;41(11):1848-50. doi: 10.1111/jog.12785. Epub 2015 Sep 24.