Ghabili Kamyar, Paulson Nathan, Syed Jamil S, Nawaf Cayce B, Khajir Ghazal, Martin Darryl T, Onofrey John, Leapman Michael S, Levi Angelique, Weinreb Jeffrey C, Humphrey Peter A, Sprenkle Preston C
Department of Urology, Yale University School of Medicine, New Haven, CT, USA.
Department of Pathology, Yale University School of Medicine, New Haven, CT, USA.
Case Rep Urol. 2021 Mar 17;2021:2687416. doi: 10.1155/2021/2687416. eCollection 2021.
The utility of serial Decipher biopsy scores in a true active surveillance population is still unknown. In a man on active surveillance for low-risk prostate cancer, a doubling of the Decipher biopsy score within genomic low-risk category from first to the second biopsy related to biopsy reclassification to Gleason grade group 4 on the third biopsy. However, the final pathology at radical prostatectomy showed Gleason grade group 2 with an organ-confined disease. This case suggests that the genomic risk category of Decipher biopsy scores during active surveillance may be more informative than either the interval genomic score change or the biopsy Gleason grade group.
在真正的主动监测人群中，连续的Decipher活检评分的效用仍然未知。在一名接受低风险前列腺癌主动监测的男性中，在基因组低风险类别内，从第一次活检到第二次活检，Decipher活检评分翻倍，这与第三次活检时活检重新分类为Gleason分级组4相关。然而，根治性前列腺切除术时的最终病理显示为Gleason分级组2且疾病局限于器官内。该病例表明，主动监测期间Decipher活检评分的基因组风险类别可能比基因组评分的间隔变化或活检Gleason分级组更具信息价值。
