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本文引用的文献

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Prognostic value of urinary prostate cancer antigen 3 (PCA3) during active surveillance of patients with low-risk prostate cancer receiving 5α-reductase inhibitors.尿前列腺癌抗原3（PCA3）在接受5α-还原酶抑制剂治疗的低风险前列腺癌患者主动监测期间的预后价值
BJU Int. 2018 Mar;121(3):399-404. doi: 10.1111/bju.14041. Epub 2017 Oct 25.
2
PTEN Loss but Not ERG Expression in Diagnostic Biopsies Is Associated with Increased Risk of Progression and Adverse Surgical Findings in Men with Prostate Cancer on Active Surveillance.在接受主动监测的前列腺癌男性中，诊断性活检中存在 PTEN 缺失但不存在 ERG 表达与进展风险增加和不良手术发现相关。
Eur Urol Focus. 2018 Dec;4(6):867-873. doi: 10.1016/j.euf.2017.03.004. Epub 2017 Mar 22.
3
Shift from protocol-based to personalized medicine in active surveillance: beginning of a new era.
BJU Int. 2017 Jul;120(1):3-4. doi: 10.1111/bju.13677.
4
Ability of a Genomic Classifier to Predict Metastasis and Prostate Cancer-specific Mortality after Radiation or Surgery based on Needle Biopsy Specimens.基于针吸活检标本的基因组分类器预测放射或手术后转移和前列腺癌特异性死亡率的能力。
Eur Urol. 2017 Nov;72(5):845-852. doi: 10.1016/j.eururo.2017.05.009. Epub 2017 May 19.
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Prognostic utility of biopsy-derived cell cycle progression score in patients with National Comprehensive Cancer Network low-risk prostate cancer undergoing radical prostatectomy: implications for treatment guidance.活检衍生的细胞周期进展评分在接受根治性前列腺切除术的美国国立综合癌症网络低风险前列腺癌患者中的预后效用：对治疗指导的意义
BJU Int. 2017 Dec;120(6):808-814. doi: 10.1111/bju.13911. Epub 2017 Jun 11.
6
Use of a 17-Gene Prognostic Assay in Contemporary Urologic Practice: Results of an Interim Analysis in an Observational Cohort.17基因预后检测在当代泌尿外科实践中的应用：一项观察性队列的中期分析结果
Urology. 2017 Sep;107:67-75. doi: 10.1016/j.urology.2017.02.052. Epub 2017 Apr 25.
7
Longitudinal assessment of urinary PCA3 for predicting prostate cancer grade reclassification in favorable-risk men during active surveillance.对 PCA3 尿液指标进行纵向评估，以预测在积极监测期间低危男性中前列腺癌分级的重新分类。
Prostate Cancer Prostatic Dis. 2017 Sep;20(3):339-342. doi: 10.1038/pcan.2017.16. Epub 2017 Apr 18.
8
An Update of the American Urological Association White Paper on the Prevention and Treatment of the More Common Complications Related to Prostate Biopsy.美国泌尿外科学会关于预防和治疗前列腺活检相关常见并发症白皮书更新版。
J Urol. 2017 Aug;198(2):329-334. doi: 10.1016/j.juro.2017.01.103. Epub 2017 Mar 29.
9
Prostate Health Index density improves detection of clinically significant prostate cancer.前列腺健康指数密度可改善临床显著性前列腺癌的检测。
BJU Int. 2017 Dec;120(6):793-798. doi: 10.1111/bju.13762. Epub 2017 Feb 6.
10
Evaluating the Four Kallikrein Panel of the 4Kscore for Prediction of High-grade Prostate Cancer in Men in the Canary Prostate Active Surveillance Study.评估 Canary 前列腺主动监测研究中 4Kscore 的四个 Kallikrein 面板对预测男性高级别前列腺癌的价值。
Eur Urol. 2017 Sep;72(3):448-454. doi: 10.1016/j.eururo.2016.11.017. Epub 2016 Nov 23.

主动监测中的生物标志物。

Biomarkers in active surveillance.

作者信息

Loeb Stacy, Tosoian Jeffrey J

机构信息

Department of Urology, New York University, New York, NY, USA.

Population Health, New York University, New York, NY, USA.

出版信息

Transl Androl Urol. 2018 Feb;7(1):155-159. doi: 10.21037/tau.2017.12.26.

DOI:10.21037/tau.2017.12.26
PMID:29594029
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5861276/
Abstract

The use of active surveillance (AS) is increasing for favorable-risk prostate cancer. However, there remain challenges in patient selection for AS, due to the limitations of current clinical staging. In addition, monitoring protocols relying on serial biopsies is invasive and presents risks such as infection. For these reasons, there is substantial interest in identifying markers that can be used to improve AS selection and monitoring. In this article, we review the evidence on serum, urine and tissue markers in AS.

摘要

对于低危前列腺癌，主动监测（AS）的应用正在增加。然而，由于当前临床分期的局限性，在AS的患者选择方面仍存在挑战。此外，依赖系列活检的监测方案具有侵入性，并存在感染等风险。基于这些原因，人们对识别可用于改善AS选择和监测的标志物有着浓厚兴趣。在本文中，我们综述了关于AS中血清、尿液和组织标志物的证据。