Student Research Committee, Jiroft University of Medical Sciences, Jiroft, Iran.
Student Research Committee, Department of Clinical Biochemistry, School of Medicine, Shahid Beheshti University of Medical Sciences, Iran.
Biomed Res Int. 2021 Apr 14;2021:6667047. doi: 10.1155/2021/6667047. eCollection 2021.
The novel coronavirus disease 2019 (COVID-19) is the cause of an acute respiratory illness which has spread around the world. The virus infects the host by binding to the angiotensin-converting enzyme 2 (ACE2) receptors. Due to the presence of ACE2 receptors in the kidneys and gastrointestinal (GI) tract, kidneys and GI tract damage arising from the virus can be seen in patients and can cause acute conditions such as acute kidney injury (AKI) and digestive problems for the patient. One of the complications of kidneys and GI involvement in COVID-19 is fluid and electrolyte disturbances. The most common ones of these disorders are hyponatremia, hypernatremia, hypokalemia, hypocalcemia, hypochloremia, hypervolemia, and hypovolemia, which if left untreated, cause many problems for patients and even increase mortality. Fluid and electrolyte disturbances are more common in hospitalized and intensive care patients. Children are also at greater risk for fluid and electrolyte disturbances complications. Therefore, clinicians should pay special attention to the fluid and electrolyte status of patients. Changes in fluid and electrolyte levels can be a good indicator of disease progression.
新型冠状病毒病 2019(COVID-19)是一种急性呼吸道疾病的病因,已在全球范围内传播。该病毒通过与血管紧张素转换酶 2(ACE2)受体结合来感染宿主。由于肾脏和胃肠道(GI)中存在 ACE2 受体,因此可以在患者中看到由该病毒引起的肾脏和胃肠道损害,并导致急性病症,例如急性肾损伤(AKI)和患者的消化问题。COVID-19 中肾脏和胃肠道受累的并发症之一是液体和电解质紊乱。这些疾病中最常见的是低钠血症、高钠血症、低钾血症、低钙血症、低氯血症、高血容量和低血容量,如果不进行治疗,会给患者带来许多问题,甚至会增加死亡率。液体和电解质紊乱在住院和重症监护患者中更为常见。儿童也更容易发生液体和电解质紊乱并发症。因此,临床医生应特别注意患者的液体和电解质状况。液体和电解质水平的变化可能是疾病进展的良好指标。