Department of Preventive and Restorative Dentistry, College of Dental Medicine, University of Sharjah, Sharjah, UAE.
Private Consultant, Fort Lauderdale, FL, USA.
Int Endod J. 2021 Sep;54(9):1482-1490. doi: 10.1111/iej.13542. Epub 2021 Jun 13.
Reproducible, skilfully conducted and unbiased laboratory studies provide new knowledge, which can inform clinical research and eventually translate into better patient care. To help researchers improve the quality and reproducibility of their research prior to a publication peer-review, this paper describes the process that was followed during the development of the Preferred Reporting Items for Laboratory studies in Endodontology (PRILE) 2021 guidelines and which used a well-documented consensus-based methodology. A steering committee was created with eight individuals (PM, RO, OP, IR, JS, EP, JJ and SP), plus the project leaders (PD, VN). The steering committee prepared an initial checklist by combining and adapting items from the modified Consolidated Statement of Reporting Trials checklist for reporting in vitro studies of dental materials and the Clinical and Laboratory Images in Publications principles as well as adding several new items. The steering committee then formed a PRILE Delphi Group (PDG) and PRILE Online Meeting Group (POMG) to provide expert advice and feedback on the initial draft checklist and flowchart. The members of the PDG participated in an online Delphi process to achieve consensus on the items within the PRILE 2021 checklist and the accompanying flowchart for clarity and suitability. The PRILE checklist and flowchart developed by the online Delphi process were discussed further by the POMG. This online meeting was conducted on 12 February 2021 via the Zoom platform. Following this meeting, the steering committee developed a final version of the PRILE 2021 guidelines and flowchart, which was piloted by several authors when writing up a laboratory study for publication. Authors are encouraged to use the PRILE 2021 guidelines and flowchart to improve the clarity, completeness and quality of reports describing laboratory studies in Endodontology. The PRILE 2021 checklist and flowchart are freely available and downloadable from the Preferred Reporting Items for study Designs in Endodontology website (http://pride-endodonticguidelines.org/prile/).
可重复、熟练进行且无偏倚的实验室研究提供新知识，可为临床研究提供信息，并最终转化为更好的患者护理。为了帮助研究人员在发表前的同行评审中提高研究的质量和可重复性，本文描述了在牙髓病学实验室研究的首选报告项目（PRILE）2021 指南的制定过程，该过程使用了记录完善的基于共识的方法。成立了一个指导委员会，由 8 人（PM、RO、OP、IR、JS、EP、JJ 和 SP）组成，加上项目负责人（PD、VN）。指导委员会通过结合和改编改良的牙科材料体外研究报告综合声明检查表以及出版物临床和实验室图像原则中的项目，并添加了几个新项目，编写了一份初始检查表。指导委员会随后组建了一个 PIRL 德尔菲小组（PDG）和 PIRL 在线会议小组（POMG），为初始检查表草案和流程图提供专家建议和反馈。PDG 成员参与了在线德尔菲流程，就 PRILE 2021 检查表和流程图内的项目达成共识，以确保其清晰性和适宜性。在线德尔菲流程制定的 PIRL 检查表和流程图由 POMG 进一步讨论。此次在线会议于 2021 年 2 月 12 日通过 Zoom 平台进行。会议结束后，指导委员会制定了 PRILE 2021 指南和流程图的最终版本，几名作者在撰写实验室研究报告时对其进行了试点。鼓励作者使用 PRILE 2021 指南和流程图来提高描述牙髓病学实验室研究报告的清晰度、完整性和质量。PRILE 2021 检查表和流程图可在牙髓病学研究设计的首选报告项目网站（http://pride-endodonticguidelines.org/prile/）免费下载。
