多普勒引导声敏注射导管：通过功效测试动物模型评估的透壁递送。
Doppler-Guided Acoustically Active Injection Catheter: Transendocardial Delivery Assessed by an Efficacy Testing Animal Model.
机构信息
Department of Cardiovascular Diseases, Mayo Clinic, Scottsdale, Arizona, USA.
Department of Comparative Medicine, Mayo Clinic, Scottsdale, Arizona, USA.
出版信息
J Ultrasound Med. 2022 Mar;41(3):749-762. doi: 10.1002/jum.15739. Epub 2021 May 3.
Abstract
Percutaneous transendocardial injections of therapeutic agents into the myocardium may not always be effective. We used an animal model for assessing the efficacy of the injections using linoleic acid as a testing agent. Efficacious delivery into the myocardium of a beating heart was indicated by rapidly developed local myocardial necrosis and wall motion abnormalities using echocardiography. We employed this experimental model to test our innovative technology, an acoustically active injection catheter. The Doppler ultrasound-guided acoustically active injection catheter effectively delivers the substance to the myocardium but needs further technical improvements to minimize an unwanted systemic distribution of the agent.
摘要
经皮心内膜内注射治疗剂到心肌不一定总是有效。我们使用动物模型，用亚油酸作为检测剂，评估注射的效果。使用超声心动图，通过迅速发展的局部心肌坏死和壁运动异常，表明在跳动的心脏中心肌内的有效注射。我们采用这种实验模型来测试我们的创新技术，即声激活注射导管。多普勒超声引导的声激活注射导管可有效地将物质递送到心肌，但需要进一步的技术改进，以最小化药物的不必要的全身分布。
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