Department of Dermatology, Mayo Clinic, Jacksonville, FL;
Department of Dermatology, Mayo Clinic, Jacksonville, FL.
Skinmed. 2021 Apr 1;19(2):137-141. eCollection 2021.
A 63-year-old woman from Central Florida presented to an outside clinic with a 2-year history of a progressive, asymptomatic cutaneous eruption and arthralgias. Her past medical history was significant for reported seronegative rheumatoid arthritis, for which adalimumab, methotrexate, and low-dose prednisone therapy were initiated 5 years prior. The skin eruption occurred shortly after a 4-week hospitalization during which these medications were withheld. At her initial outside evaluation, a biopsy was performed and interpreted as subacute cutaneous lupus erythematosus (SCLE). She was treated with hydroxychloroquine without improvement. A repeat biopsy was reported as consistent with interstitial granulomatous dermatitis (IGD). There was no improvement with potent topical corticosteroids.
一位来自佛罗里达州中部的 63 岁女性，因进行性无症状皮肤疹和关节痛就诊于一家外诊诊所。她的既往病史包括曾报告血清阴性类风湿关节炎，5 年前开始接受阿达木单抗、甲氨蝶呤和低剂量泼尼松治疗。皮疹发生在停用这些药物的 4 周住院治疗后不久。在她最初的外诊评估中，进行了活检，并被诊断为亚急性皮肤型红斑狼疮（SCLE）。她接受羟氯喹治疗，但没有改善。重复活检报告为间质性肉芽肿性皮炎（IGD）。强效局部皮质类固醇治疗也没有改善。
