Division of Gastroenterology and Hepatology, University of Toronto, Toronto, ON, M5G 1X5, Canada.
Division of Gastroenterology, University of Alberta, Edmonton, AB, T6G 2G3, Canada.
Dig Dis Sci. 2022 Sep;67(9):4269-4277. doi: 10.1007/s10620-021-06998-0. Epub 2021 May 3.
Factors affecting pregnancy-related knowledge in women with inflammatory bowel disease (IBD) remain unknown. We aimed to determine these factors and to assess the impact of a dedicated pregnancy clinic on improving knowledge in women with IBD.
Adult women with IBD attending the pregnancy IBD clinic at the University of Alberta from 2014 to 2018 were enrolled. Each patient completed the Crohn's and Colitis Pregnancy Knowledge (CCPKnow) questionnaire at baseline and after individualized education delivered at each clinic visit. Knowledge levels were defined as very good if CCPKnow scores ≥ 14. Mean CCPKnow scores were reported with standard deviations (SD) and compared using the paired T test.
The mean CCPKnow score in 117 patients at baseline was 9.65 (SD 4.18). Compared to those with disease duration < 5 years, those with disease duration > 5 years had higher rates of very good baseline knowledge (3.0% vs. 26.4%, p = 0.036). Similarly, those on preconception IBD-related therapy were more likely to have very good knowledge compared to those on no therapy (22.5% vs. 0%, p = 0.024). Fifty-one patients completed a post-clinic CCPKnow survey with a mean CCPKnow of 10.72 (SD 4.32). Participation in a pregnancy clinic improved reproductive knowledge in those with ulcerative colitis (p = 0.001), disease duration > 5 years (p = 0.017), those with at least a university education (p = 0.014) and those on IBD-related therapies (p = 0.026).
Increased disease duration and preconception IBD-related therapy may be associated with increased pregnancy-related knowledge. A dedicated pregnancy clinic can improve reproductive knowledge in women with IBD.
影响炎症性肠病（IBD）女性妊娠相关知识的因素尚不清楚。我们旨在确定这些因素，并评估专门的妊娠诊所对提高 IBD 女性知识水平的影响。
2014 年至 2018 年，在阿尔伯塔大学妊娠 IBD 诊所就诊的成年 IBD 女性患者入组。每位患者在基线时和每次就诊时接受个体化教育后完成克罗恩病和结肠炎妊娠知识（CCPKnow）问卷。如果 CCPKnow 评分≥14，则知识水平定义为非常好。报告了平均 CCPKnow 评分和标准差（SD），并使用配对 t 检验进行比较。
117 例患者的基线 CCPKnow 评分平均为 9.65（SD 4.18）。与疾病病程<5 年的患者相比，疾病病程>5 年的患者具有更高的基线知识非常好率（3.0%对 26.4%，p=0.036）。同样，与未接受任何治疗的患者相比，接受孕前 IBD 相关治疗的患者更有可能具有非常好的知识（22.5%对 0%，p=0.024）。51 例患者完成了诊所后的 CCPKnow 调查，平均 CCPKnow 得分为 10.72（SD 4.32）。妊娠诊所的参与提高了溃疡性结肠炎患者（p=0.001）、疾病病程>5 年患者（p=0.017）、至少接受过大学教育的患者（p=0.014）和接受 IBD 相关治疗的患者（p=0.026）的生殖知识。
疾病病程的延长和孕前 IBD 相关治疗可能与妊娠相关知识的增加有关。专门的妊娠诊所可以提高 IBD 女性的生殖知识。
