1Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.
2Ministry of Health, Government of the Republic of Zambia, Lusaka, Zambia.
Am J Trop Med Hyg. 2021 May 3;104(6):2229-2232. doi: 10.4269/ajtmh.20-1669.
Zambia conducted a measles and rubella (MR) vaccination campaign targeting children 9 months to younger than 15 years of age in 2016. This campaign was the first introduction of a rubella-containing vaccine in Zambia. To evaluate the impact of the campaign, we compared the MR seroprevalence estimates from serosurveys conducted before and after the campaign in Southern Province, Zambia. The measles seroprevalence increased from 77.8% (95% confidence interval [CI], 73.2-81.9) to 96.4% (95% CI, 91.7-98.5) among children younger than 15 years. The rubella seroprevalence increased from 51.3% (95% CI, 45.6-57.0) to 98.3% (95% CI, 95.5-99.4). After the campaign, slightly lower seroprevalence remained for young adults 15 to 19 years old, who were not included in the campaign because of their age. These serosurveys highlighted the significant impact of the vaccination campaign and identified immunity gaps for those beyond the targeted vaccination age. Continued monitoring of population immunity can signal the need for future targeted vaccination strategies.
赞比亚于 2016 年针对 9 个月至 15 岁以下儿童开展了麻疹和风疹（MR）疫苗接种运动。这是赞比亚首次引入含风疹成分的疫苗。为了评估该运动的影响，我们比较了赞比亚南部省在运动前后进行的血清学调查中的 MR 血清阳性率估计值。麻疹血清阳性率从 77.8%（95%置信区间[CI]，73.2-81.9）增加到 96.4%（95%CI，91.7-98.5），15 岁以下儿童的血清阳性率增加。风疹血清阳性率从 51.3%（95%CI，45.6-57.0）增加到 98.3%（95%CI，95.5-99.4）。运动后，15 至 19 岁的年轻成年人的血清阳性率略有下降，他们因年龄原因未被包括在运动中。这些血清学调查强调了疫苗接种运动的重大影响，并确定了超出目标接种年龄人群的免疫空白。持续监测人群免疫情况可以表明需要制定未来有针对性的疫苗接种策略。
