Changsha Environment Protection College, Changsha, Hunan, China.
Hunan Province Maternal and Children Care Hospital, Changsha, Hunan, China.
PLoS One. 2021 May 3;16(5):e0251108. doi: 10.1371/journal.pone.0251108. eCollection 2021.
To investigate the effects of short-term exposure to sulfur dioxide (SO2) and carbon monoxide (CO) in the central and southern China areas on ischemic heart disease (IHD) and non-accidental deaths.
We investigated the associations between short-term exposure to SO2 and CO in a city in south-central China and IHD and non-accidental death using a time-series design and generalized additive models with up to a 5-day lag adjusting for day of the week, temperature, air pressure, wind speed, and relative humidity. The relative risks of IHD and non-accidental death per 10-unit increase in SO2 and CO were derived from zero to five days in single-pollutant models.
Between 2016 and 2018, a total of 10,507 IHD and 44,070 non-accidental deaths were identified. The largest significant relative risk for IHD death was lag 02 for both SO2 (1.080; 95% confidence interval: 1.075-1.084) and CO (5.297; 95% confidence interval: 5.177-5.418) in single-pollutants models. A significant association was shown at all lag multiple-day moving averages. Two-pollutant models identified an association between SO2 and mortality when adjusting for CO. In stratified analyses, SO2 exhibited a stronger association with death during the cold season, while CO exhibited a stronger association with mortality from IHD during the warm season. The risk of death was more robust in the elderly for both pollutants, but was greater in men for CO and in women for SO2.
Overall, we found an association between short-term exposure to low-level SO2 and CO and the risk of IHD and non-accidental death.
本研究旨在调查中国中南部地区短期二氧化硫（SO2）和一氧化碳（CO）暴露对缺血性心脏病（IHD）和非意外死亡的影响。
采用时间序列设计和广义相加模型，在调整了星期几、温度、气压、风速和相对湿度等因素后，研究了中国中南部某城市短期 SO2 和 CO 暴露与 IHD 和非意外死亡之间的关系。在单污染物模型中，得出了 SO2 和 CO 每增加 10 个单位时 IHD 和非意外死亡的相对风险。
在 2016 年至 2018 年期间，共确定了 10507 例 IHD 和 44070 例非意外死亡。在单污染物模型中，SO2 和 CO 对 IHD 死亡的最大显著相对风险均出现在滞后 02 时，分别为 1.080（95%置信区间：1.075-1.084）和 5.297（95%置信区间：5.177-5.418）。在多日移动平均的所有滞后时间均显示出显著的相关性。双污染物模型表明，在调整 CO 后，SO2 与死亡率之间存在关联。分层分析显示，SO2 与寒冷季节的死亡相关性更强，而 CO 与温暖季节的 IHD 死亡率相关性更强。两种污染物的死亡风险在老年人中更为显著，但 CO 在男性中更为显著，SO2 在女性中更为显著。
总的来说，我们发现短期暴露于低水平的 SO2 和 CO 与 IHD 和非意外死亡的风险之间存在关联。
