Department of Endocrinology and Diabetes, Diabetes Treatment Center, Prince Sultan Military Medical City, Riyadh, Saudi Arabia.
Department of Radiodiagnostics and Medical Imaging, Prince Sultan Military Medical City, Riyadh, Saudi Arabia.
Diabetes Metab Syndr. 2021 May-Jun;15(3):955-961. doi: 10.1016/j.dsx.2021.04.008. Epub 2021 Apr 20.
This study aimed to estimate the prevalence of bone fractures and analyze their associated risk factors in people with and without type 2 diabetes (T2D) in Saudi Arabia.
This study was conducted among 1188 people (581 type 2 diabetes) in Prince Sultan Military Medical City, Riyadh, Saudi Arabia. In addition to the demographic variables, glycated hemoglobin (HbA1c), creatinine, estimated glomerular filtration rate (eGFR), use of teriparatide, presence of rheumatoid arthritis, presence of chronic obstructive pulmonary disease (COPD), Bone mineral density (BMD), Trabecular Bone Score (TBS) and Fracture Risk using the Fracture Risk Assessment Tool (FRAX) were also collected.
There were 1188 people (mean age 66.5 ± 8.7yrs) included in this study, of which 1068 (89.9%) were female, and 120 (10.1%) were male. A total of 112 (9.4%) individuals had a fracture history. Female, use of teriparatide, TBS (partially degraded and degraded), FRAX with TBS (MOF), and FRAX with TBS (Hip fx) were identified as independent risk factors for fracture in the whole study population. Teriparatide use and FRAX with TBS (MOF) were observed as independent risk factors for fracture in the non-diabetic population, whereas age, creatinine, eGFR, teriparatide, osteopenia, osteoporosis, TBS (partially degraded, degraded), FRAX with TBS (MOF), FRAX with TBS (Hip fx) were determined as independent risk factors for fracture among patients with diabetes.
Patients with T2D were observed to have a higher risk for fractures. The findings of the study highlight the requirement for fracture prevention strategies in patients with diabetes.
本研究旨在估计沙特阿拉伯 2 型糖尿病（T2D）患者和非 T2D 患者骨折的患病率，并分析其相关危险因素。
本研究在沙特阿拉伯利雅得的苏丹亲王军事医学城对 1188 人（581 例 T2D）进行了研究。除了人口统计学变量外，还收集了糖化血红蛋白（HbA1c）、肌酐、估算肾小球滤过率（eGFR）、特立帕肽的使用情况、类风湿关节炎、慢性阻塞性肺疾病（COPD）、骨密度（BMD）、Trabecular Bone Score（TBS）和使用骨折风险评估工具（FRAX）评估的骨折风险。
本研究共纳入 1188 人（平均年龄 66.5±8.7 岁），其中 1068 人（89.9%）为女性，120 人（10.1%）为男性。共有 112 人（9.4%）有骨折史。女性、特立帕肽的使用、TBS（部分降解和降解）、FRAX 与 TBS（MOF）和 FRAX 与 TBS（髋部骨折）被确定为全人群骨折的独立危险因素。在非糖尿病人群中，特立帕肽的使用和 FRAX 与 TBS（MOF）被观察为骨折的独立危险因素，而年龄、肌酐、eGFR、特立帕肽、骨量减少、骨质疏松症、TBS（部分降解、降解）、FRAX 与 TBS（MOF）、FRAX 与 TBS（髋部骨折）被确定为糖尿病患者骨折的独立危险因素。
T2D 患者骨折风险较高。研究结果强调了在糖尿病患者中实施骨折预防策略的必要性。
