Buchweitz John P, Johnson Margaret, Wixson Margaret, Puschner Birgit
Michigan State University Veterinary Diagnostic Laboratory, College of Veterinary Medicine, Michigan State University, 4125 Beaumont Rd, Lansing, MI 48910, USA.
Department of Pathobiology and Diagnostic Investigation, College of Veterinary Medicine, Michigan State University, 784 Wilson Rd, East Lansing, MI 48824, USA.
J Anal Toxicol. 2021 May 3. doi: 10.1093/jat/bkab043.
The production and use of the highly addictive stimulant methamphetamine are a serious public health problem in the United States and globally. Because of its increased popularity with recreational drug users, accidental or intentional poisoning incidents in companion animals have become an unavoidable scenario in veterinary medicine. We describe a case of methamphetamine poisoning in a 4-year-old female German Shepherd with postmortem analytical quantitation of methamphetamine and its metabolite, amphetamine, in bodily tissues and fluids. Many tissues and bodily fluids can be tested to confirm methamphetamine exposure. More importantly, the higher concentrations found in stomach contents, liver, kidney and heart tissue suggest these are the most useful diagnostic specimens for postmortem confirmation of toxicosis in pets especially in cases in which source material is not available for testing or in cases with no postmortem evaluation.
高成瘾性兴奋剂甲基苯丙胺的生产和使用在美国乃至全球都是一个严重的公共卫生问题。由于其在娱乐性吸毒者中越来越受欢迎，伴侣动物意外或故意中毒事件已成为兽医学中不可避免的情况。我们描述了一例4岁雌性德国牧羊犬甲基苯丙胺中毒病例，并对其身体组织和液体中的甲基苯丙胺及其代谢物苯丙胺进行了死后分析定量。可以检测许多组织和体液以确认甲基苯丙胺暴露情况。更重要的是，在胃内容物、肝脏、肾脏和心脏组织中发现的较高浓度表明，这些是死后确认宠物中毒最有用的诊断标本，特别是在没有源材料可供检测或没有进行死后评估的情况下。
