Department of Social Medicine, Postgraduate Program in Epidemiology, Federal University of Pelotas, Pelotas, Brazil.
Departamento de Medicina Preventiva, Faculdade de Medicina FMUSP, Universidade de São Paulo, São Paulo, SP, Brazil.
J Dev Orig Health Dis. 2022 Apr;13(2):161-167. doi: 10.1017/S2040174421000179. Epub 2021 May 4.
Evidence suggests that maternal prepregnancy body mass index (BMI) is associated with offspring cardiometabolic risk factors. This study was aimed at assessing the association of maternal prepregnancy BMI with offspring cardiometabolic risk factors in adolescence and adulthood. We also evaluated whether offspring BMI was a mediator in this association. The study included mother-offspring pairs from three Pelotas birth cohorts. Offspring cardiometabolic risk factors were collected in the last follow-up of each cohort [mean age (in years) 30.2, 22.6, 10.9]. Blood pressure was measured using an automatic device, cholesterol by using an enzymatic colorimetric method, and glucose from fingertip blood, using a portable glucose meter. In a pooled analysis of the cohorts, multiple linear regression was used to control for confounding. Mediation analysis was conducted using G-computation formula. In the adjusted model, mean systolic blood pressure of offspring from overweight and obese mothers was on average 1.25 (95% CI: 0.45; 2.05) and 2.13 (95% CI: 0.66; 3.59) mmHg higher than that of offspring from normal-weight mothers; for diastolic blood pressure, the means were 0.80 (95% CI: 0.26; 1.34) and 2.60 (95% CI: 1.62; 3.59) mmHg higher, respectively. Non-HDL cholesterol was positively associated with maternal BMI, whereas blood glucose was not associated. Mediation analyses showed that offspring BMI explained completely the association of maternal prepregnancy BMI with offspring systolic and diastolic blood pressure, and non-HDL cholesterol. Our findings suggest that maternal prepregnancy BMI is positively associated with offspring blood pressure, and blood lipids, and this association is explained by offspring BMI.
有证据表明，母体孕前体重指数（BMI）与后代心血管代谢危险因素有关。本研究旨在评估母体孕前 BMI 与后代青春期和成年期心血管代谢危险因素的关系。我们还评估了后代 BMI 是否是这种关联的中介。该研究包括来自三个佩洛塔斯出生队列的母婴对。在每个队列的最后一次随访中收集了后代的心血管代谢危险因素[平均年龄（岁）30.2、22.6、10.9]。使用自动设备测量血压，使用酶比色法测量胆固醇，使用便携式血糖仪测量指尖血糖。在对队列的汇总分析中，使用多元线性回归控制混杂因素。使用 G 计算公式进行中介分析。在调整后的模型中，超重和肥胖母亲的后代平均收缩压比正常体重母亲的后代高 1.25（95%CI：0.45；2.05）和 2.13（95%CI：0.66；3.59）mmHg；对于舒张压，平均值分别高出 0.80（95%CI：0.26；1.34）和 2.60（95%CI：1.62；3.59）mmHg。非高密度脂蛋白胆固醇与母体 BMI 呈正相关，而血糖与母体 BMI 无相关性。中介分析表明，后代 BMI 完全解释了母体孕前 BMI 与后代收缩压和舒张压以及非高密度脂蛋白胆固醇的关系。我们的研究结果表明，母体孕前 BMI 与后代血压和血脂呈正相关，这种相关性由后代 BMI 解释。
