Ulinskaĭte A P, Krauialis K I, Diashrius A P
Ukr Biokhim Zh (1978). 1988 Mar-Apr;60(2):16-20.
The study of transcortin role in 3H-corticosterone metabolism has shown that transcortin of blood plasma from rats bearing Walker carcinosarcoma preserves the hormone conversion to dihydrocompounds 4 time less intensively than transcortin taken from healthy rats. Inactivated transcortin exerts no effect on the rate of formation of 5 beta-metabolites. Under the influence of homogeneous transcortin samples, a decrease in the content of 5 beta-reduced corticosterone metabolites is revealed to occur depending on transcortin concentration in the system. It is shown that in incubation systems where hormone is in the bound state the metabolism preserving capacity of transcortin depends on the temperature degree. The transcortin activity on corticosterone metabolism is supposed to be closely related to the intensity of its complexing with transcortin.
对运皮质素在3H-皮质酮代谢中作用的研究表明，携带沃克癌肉瘤的大鼠血浆中的运皮质素使激素转化为二氢化合物的强度比从健康大鼠获取的运皮质素低4倍。失活的运皮质素对5β-代谢产物的形成速率没有影响。在均一的运皮质素样品的影响下，发现5β-还原皮质酮代谢产物的含量会根据系统中运皮质素的浓度而降低。结果表明，在激素处于结合状态的孵育系统中，运皮质素的代谢维持能力取决于温度。运皮质素对皮质酮代谢的活性被认为与其与运皮质素的络合强度密切相关。
