[Chromatographic transcortin analysis of the blood plasma in tumor-bearing rats].

The binding of 3H corticosterone was studied comparatively in partly purified preparations of blood plasma transcortin in intact and tumor-bearing rats at the 12th day after transplantation. By means of chromatography on DEAE-cellulose and hydroxylapatite transcortin was purified about 200 times. It was demonstrated that the content of bound 3H corticosterone in 1 mg of protein in blood plasma preparations from tumor-bearing animals is 3.5 times less than in the plasma of intact rats. The observed reduction of the transcortin binding capacity in the blood plasma of rats with Walker carcinosarcoma is retained also in purified preparations of the blood plasma tanscortin of tumor-bearing rats.